The available information on T3 dosing - both dose size and timing is downright scary....many places list 25mcg (!!!) as the starting dose to be taken once daily.
It seems that, with treating thyroid disease, we have to do our own research and can also benefit from the experiences of others....I'm sure you've already discovered this
Dr. Ridha Arem mentions the split dosing in his book "The Thyroid Solution" and it makes sense since Cytomel has a short half-life.
Yes, on the day of my lab, I take my 8AM Cytomel dose....and then lab at 1PM.
Cytomel supposedly peaks within 2-4 hours after taking it....and I'm sure it's quite "individual-specific" as many things thyroid can be
I most definitely saw a bump in my Free T3 level - it was 3.0 (2.0-4.4) when I started 5mcg Cytomel (split into 2 doses).... and I "landed" right at my setpoint - 4.0 after 4 wks.
The labs I had done today (get results on Monday) will constitute 8 wks. on the 5mcg. Now, this past Monday, I started to have afternoon fatigue....by Wednesday, chills at night set in....yesterday, my knees started aching - these are all hypo symptoms for me.
My doctor increased my levo dose to get me started feeling back to my old self and then, after the lab results come back Monday, we'll finalize my dose moving forward.
I was supposed to have labs Tuesday but had to change my appointment to today since I had a slight fever on Monday (weird 5-hr virus - lol)....being sick can affect thyroid levels so I knew I had to reschedule my labs.
I'm sure my levels are a bit "off"....and, if I kept to my original lab schedule (every 4 wks.), I just might have been able to nip these early symptoms in the bud.
(admittedly, I took a full 5mcg Cytomel tab this afternoon to expedite my return to good health....I just might do 7.5mcg total/day until I get my lab results on Monday)
Dr. Ken Blanchard mentions this type of dosing when a patient needs a dose increase - he starts out higher for a few days - week and then brings the patient back down to the intended dose moving forward.
My doctor did that for me not too long ago but she had labs to back up the decision.
I know my body well enough to know I need a bit of a "jump start"....and the 3 days of higher dose Cytomel will not skew my labs in 4 weeks.....and, who knows, I just might need a Cytomel dose increase once we see my labs.
I need my FT4 to be 1.7 (.8-1.76) and my FT3 to be 4.0 (2- 4.4).
It is not correct to term a low/below-range/undetectable TSH as "hyper" when a person is taking thyroid hormone replacement meds.....that link I shared with you explains why.
But, as far as my TSH is concerned, you really can't use it as a reference since I have Graves' disease and my antibodies suppress my TSH. My TSH has always been below-range.....once I started Cytomel, it became undetectable - <.0006.
This is to be expected....those endo journals referenced by the other member's thread explains all this.