Originally Posted by akb1027
Thanks for the reply. I am starting to have a little pain in spine. However, I am having alot of pain and burning in feet, burning in ankles and knees. Also I am noticing bumps and bruises in my knees along with a feeling in my right knee like something is moving, but it is deep in my knee. I am having bone test on Friday. My urine is always a dark yellow. I am a bit nervous about all of this. I am also having many neurological symptoms such as dropping things, tingling, burning in neck at times and also in wrists. I am being followed up on all of this. It all happened so quickly. When I had my first urine test and the dr said there was protein, he said there was nothing to worry about, but now that it was in the third one and I am rapidly not feeling well, I checked the internet on bence jones and was surprised it had to do with bone marrow cancers. I have been diagnosed with monoclonal gammopathy, but again, that's something I've never heard of before. Thanks again.
Ohhh! You have been diagnosed with monoclonal gammopathy...yes, then unfortunately you are at high risk for multiple myeloma. You're right, multiple myeloma is a bone marrow cancer...it's a cancer of a subset of your white blood cells--the B-cells. To be more specific, it's a cancer of a mature, antibody secreting form of the B-cell, the plasma cell.
To understand how Multiple Myeloma works, you have to know a little bit about plasma cells. Unrelated plasma cells (i.e ones from different cell lines) each have their own unique antibody that they secrete that no other plasma cell secretes....HOWEVER, any plasma cells that are the offspring of another plasma cell (i.e. through cell division) will secrete the same antibody as its parent.
Now, in multiple myeloma, a particular plasma cell starts to divide WAAAAY out of control and it has WAAAAY too many offspring. This huge mass of plasma cells does a few things.
1. They start secreting a huge amount of antibody, which puts a huge protein load in your system which can end up gumming up your kidneys (this is the bence jones protein).
2. These plasma cells start encroaching on other good plasma cells, they are not able to make their own antibody and you become susceptible to infections.
3. The antibodies and other things that are being oversecreted by the malignant plasma cells, cause an increase in breakdown in the bone, and you can get brittle bones and fractures.....multiple myeloma often presents with symptoms of anemia + back pain.
4. The huge mass of malignant multiple myeloma cells start to encroach on the other cells being produced in the bone marrow, so this results in low platelets, low red blood cells and low white blood cells (aside from the malignant plasma cells)