Re: Can Melatonin and Vitamin B-6 cause nerve problems?
For vitamin B6 (pyridoxine) supplements, 500 mg/d has been identified to be the lowest dosage associated with observable side effects (sensory neuropathy, though reversible), while 200 mg/d is the dosage level with no observable adverse effects. Some studies have reported sensory neuropathy between 200 mg/d and 500 mg/d... Other conflicting studies exist. The time it took for adverse effects to surface varied, but duration of supplement usage ranged from a few months to a few years.
With 200 mg/d as the agreed upon dosage level that carries no observable adverse effects and taking into account an uncertainty factor, the tolerable upper limit for vitamin B6 in adults (aged 18-50) has been set to 100 mg/d.
Therefore, dosages of vitamin B6 higher than the upper limit can increase the possibility for sensory neuropathy.
Last edited by scribbles; 04-24-2004 at 08:01 AM.