"The most common St. John's wort side effect is insomnia, which is likely to be worse on higher doses. Headaches and irritability or anxiety have also been reported. Sensitivity to light is another St. John's wort side effect."
Took it once, but made my heart race and couldn't sleep all night. I haven't heard about it making medicines more potent, however I wouldn't doubt it.
On the other hand, I have heard that grapefruit juice makes medicines in particular antibiotics stronger....usually drink lots of grapefruit juice when I have a virus....cause doc always gives me the weak stuff(amoxicillin).