Yes, I can think of lots of reasons!

The ingredient list in those (the GNC) vitamins is a mile long. Some having 3000% or more of the RDA of certain items. A lot of stomachs are sensitive to excesses like these.
As for the tiredness, some people sort of feel a "crash" after any green tea (which the GNC vitamins contain).
Also - some people report irritability with excess B vits, which this is.