There are supplements that won't interact with your meds.. Gymnema, chromium, green tea (capsules), CINNAMON (capsules, those are great), apple cider vinegar (also have capsules) etc. You can do research about them with your specific meds. They worked for me over a period of months.. Also, exercise is great, as another poster mentioned I believe.. and lastly, LOSING WEIGHT. I know that sounds kind of obvious, but I lost about 65-70 lbs. over the course of a year or so, and my metabolism went through the roof. First time in my life. I couldn't believe that I could eat a burger and not gain weight.. over time, it came back down, but for a good 6 months, I was on cloud 9.