I've tried Meridia. It made me really sick. I did lose weight and it made me feel full all day long, even if I ate very little. However, I got really bad headaches and nausea while taking it, and it made me extremely cranky and bad-tempered. I gave it up after a week, during which I did lose four pounds. For me it just wasn't worth the side effects, plus it is soooo expensive. Have you tried phentermine? I have heard good things about it. Good luck.