I have taken desogen for about nine months and have had MANY problems right from the start. I am actually starting microgestin 1/20 this week because I couldn't stand the desogen. Small problems: gained ten pounds I can't lose, vaginal dryness. Huge problems: mood swings, lightheaded, irritable, anxious, and the worst thing was migranes. I never had migranes before, and the desogen gave me migranes that would last for days. I know everyone is different, but I would think about it first, because I know a lot of women who have had major problems with desogen. Besides, I think with a low dose pill, the side effects are less likely. Good luck becuase this has been such a long journey for me.