Wellbutrin claims it has a "low risk" of sexual side effects, meaning that it may not have negative effects, but most antidepressants do have this potential to cause low libido...so I hope it isn't causing your sex drive to be decreased. On a positive note, I believe the Premarin cream is given to post-menopausal women to help enhance their sex drive, help with vaginal dryness and/or painful intercourse. It contains estrogen, which is a main sex hormone. You might also want to get your testoterone levels checked...I've read that low testosterone in women can cause low libido. To answer your question about why is this happening at your age...all I can say is everyone is different. Hopefully, this Premarin will get rid of that caruncle and make you feel sexy again in no time. Good luck!