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Posted by Sybil Brabner on November 12, 2000 at 16:28:31:

My name is Sybil Brabner,

I am a 37 year old BC patient with a VERY POOR PROGNOSIS.
The stat is 3 years and you are gone--technically speaking I am (ER-,
PR-, P53+, Her/2-) nuclear grade 3 (Bloom and Richardson) I was
diagnosed in Jan of 99, Stage IIB, mastectomy, four cycles of
Adrimycin, Cytoxin, and Taxol at one time (ECOG study) 6 weeks
radiation, mets to L2 with fracture by April 1st of 2000, and on
August 31st they discovered mets to liver and lung.

The liver mets was 6.1cm x 5.9cm on October 3.

On September 26 I started taking 25mg Cytoxin (orally-I weigh 110lbs)
combined with 200mgx2 Celebrex. On my last scan my liver tumor
was 3.4cm x 3.3. Other tumors in my lung and near my spinehave disappeared altogether. Bone mets are stable I have had no side effects, save for a few hot flushes at night.
I am able to eat, exercise, have not had any immune suppression. I have quality of
life, and this is after the doctors said "6 months to a year max."

I will be happy to email anyone my radiology report to prove this --
which I have as both .JPG and a text file. I just want to help as many
people out there as I can. Anti-angiogenesis has been around for 20
years, yet people are still going through expensive surgery,
hospitalizations, 3 hour infusions, etc. We need this stuff in Clinical
Trial!! NOW!! But this "protocol" is working in me, and if you are
told "2 months" why go out miserable?

This is the article that I based my decision on, with the help of a friend
who is a biochemist in cancer research at a pharmaceutical company.

http://www.jci.org/cgi/content/full/105/8/R15

It explains how this combination of 1/4 standard dose of chemo
combined with a COX-2 inhibitor (They used Vinblastine in the mice
but there are many others available to try such as Celebrex,
Thalidomide, TNP470, DC101) chokes off the blood supply to
tumor. This is a far more humane treatment for somebody with lots of
tumor and little life expectancy. It is not in clinical trial yet, but there
are many institutions that are looking into it.

If you are metastatic with tumor in your body and are being told you
have no time, if you are tired of standard dose chemo, and being
wiped out and hospitalized you can REFUSE standard treatment and
ask that your doctor try this.

If he/she won't, find one who will. In a month you will know if it is
working, maybe even sooner. I have found that you must take your
health care into your own hands, you must educate yourself and be
your own advocate or find someone who will. If I can help please call
me

In lay terms, I explain anti-angiogenesis as if a tumor is a spider. Most
standard chemo is targeted at the spider's body (tumor cells) but this
therapy targets his legs (endothelial and stromal cells) without his legs
he can't feed himself and starves to death.

Please spread the word about this . . .I want to prevent anyone from
having to go through the horrors of Standard Dose Chemo if possible.

Sincerely,
Sybil Brabner
Chicago

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