I have been on Stacker 2 for a month now and have lost 30 lbs and have dropped from a 24 dress size to a 20. I feel great and only take 2 a day instead of the 3 a day. The pill after dinner had me in bed @ 10 pm and up @ 1am - 4 am. So, I would not suggest taking one after 5 pm. I feel great and have had no other side effects. Good luck!!!!