I personally don't think taking a hydrocodone pill with more apap (tylenol) will offer any more pain relief than a pill with a lower apap and the same amount of hydrocodone. In addition, increasing your apap intake will greatly increase your chances of long term liver damage that can be very serious. If you truely want more pain relief, you will have to increase your hydrocodone intake. For example, if you are taking vicodin 5/325, and it is inadequate, increase to vicodin 7.5/325 or to 10/325, rather than changing to vicodin 5/500. I hope that example helps you to understand what i mean. Percocet fits into the picture in that it is a preparation much like vicodin with tylenol and a narcotic. The difference being that the narcotic is oxycodone instead of hydrocodone. Oxycodone is generally somewhat stronger than hydrocodone, between 20-40% stronger milligram for milligram (however the difference can vary greatly from person to person). Oxycodone is also a schedule II narcotic, while hydrocodone is a schedule III narcotic (in most states) This means that for products containing oxycodone, including percocet, you are not allowed refills without a written perscription, the doctor cannot call the script in, you must fill the script within seven days of the date it was written, but not within 30 days of a prior prescription for the same product, or it is invalid; and it is just generally more regulated. Percocet comes in generic, and it comes in preparations similiar to vicodin including, 2.5/325, 2.5/500, 5/325, 5/550, 7.5/325, 7.5/650, 10/325, 10/650. Don't let the schedule II status of the drug scare you, it is more of a minor inconvenience than anything else, and many people find percocet to be more effective than vicodin. In fact percocet is the next logical step, once vicodin has failed. Take care.