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Posted by Alan on May 04, 2000 at 01:04:18:

In Reply to: Re: Drug that could produce ketones posted by Scott Deadwyler on December 18, 1999 at 12:37:35:

: : To the previous writer, I would also like any information on a drug that could produce ketones. Have you heard that this is a possiblity? I am interested in anything you find.

: I used to work in a hospital with diabetic kids, and I learned there that ketones are a biproduct of the body's metabolizing its own tissues. When blood sugar drops because of exertion, and isn't replaced by eating food, the body burns its own fat, and even its own muscle if there isn't any fat. Ketones are a biproduct of that metabolism. A ketogenic diet, then, is one of near-starvation and is usually a last resort.

Ketones are byproducts of fat metabolism (whether from the bodies stores or eaten). Ketones are not produced from protein metabolism (whether the bodies muscle tissue or eaten). Ketosis (ketones in the blood) are not a bad thing, actually quit normal in varying amounts, unless you are a Type I (insulin dependent) diabetic. In this condition, you can have high blood sugar levels as well as high ketones levels and enter what is called Ketoacidosis. Without the necessary insulin, blood sugar rises (when carbs and to some extent protein are eaten), but there is no mechanism to get it into the tissues for use as fuel so the body has to start burning fat. In a non-diabetic, ketones will be produced when the body begins burning fat for fuel, which typically only takes place after all of it's carbohydrate stores are depleted. Ketosis can be entered due to starvation or due to limited carbohydrate consumption (like in the Atkins low carb diet). Ketosis due to carbohydrate restriction has no known ill effects.
A ketogenic diet has been used to successfully treat epileptic children. For more info just do an internet search for ketogenic and epilepsy. I know of no drug that produces ketones. Alan

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