Have you tried absolutely every, single solitary preventative drug?? As I posted in another message, I had tried everything and was so disappointed and just gave up a few years ago. But got so much worse by managing the daily migs with things that cause more rebound. There are some newer preventative meds that might be worth a try--like topamax. Then there's also the botox injections. I have tried both and have had some relief. Don't give up. Try everything!! There might be just that one medication that works for you.