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Posted by Bruce on August 31, 2000 at 20:32:47:

In Reply to: Apomorphine, another miracle drug? posted by Betty D. on August 31, 2000 at 13:52:18:

: Bruce,
: Would you post your research results on the drug, Apomorphine? I know it is legally used in Europe, and can be purchased (with script) in Canada. It is available in injection form only now, but understand it will be available in tab or cap form soon.
: Betty D.

Betty D, Apomorphine is a dopamine agonist drug, which means it acts directly on the dopamine receptors in the brain. I do remember reading that the drug is not commercially available in the U.S,, but approval was likely. Also research centers can use the drug for investigational reasons in the U.S. The drug is usually used on patients with advanced pd and can be used to counter the effects seen after long term levodopa therapy. It can be used on top of levodopa to control symptoms of dystonia, akinesia and rigidity. Apomorphine acts quickly, helping over 50 % of patients within 5-10 minutes. Its effect lasts one hour and enables patients with levodopa fluctuations to continue normal activities. Used in advanced pd, apomorphine reverses the levodopa off period. It is preently administered by subcutaneous injections in the abdomen, thigh or arm. Side efects were stated to be mild and include increased confusion, personality changes and impairment of voluntary movement during the "on"period possibly resulting in cessation of therapy. One interesting thing I read was their seemed tobe more interest in the drug as a treatmebt for male impotence in this country. Bruce

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