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  High & Low Blood Pressure
  Anyone take Cardura or other alpha blockers?

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Tick Tock
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From:USA
Registered: Aug 2003

posted 08-20-2003 12:12 AM     Click Here to See the Profile for Tick Tock     Edit/Delete Message   Reply w/Quote
My BP has been running about 145/90. I have cut down on salt, been running 3 miles nearly every day and lost about 15 lbs. I then started taking Atacand (an ARB) and am up to the max. dose of 32mg/day. My BP after all this is now about 150/100. I continue to take the Atacand.

I can't take any of the usual diuretics because I'm extremely allergic to sulfa. This rules out HCT, etc.

I started taking Cardura 1mg/day last week. I am curious to hear from anyone else that has taking this class of drugs (alpha blockers) and how it's worked, etc.

My doc plans to increase the Cardura slowly and likely add a potassium sparing diuretic.

Any comments on this plan?

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zuzu8
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From: California, U.S.A.
Registered: Jan 2003

posted 08-21-2003 05:22 AM     Click Here to See the Profile for zuzu8     Edit/Delete Message   Reply w/Quote

Hi Tick Tock...
I see that your post is getting read but no responses yet...probably because few of us have had experience with the alpha blockers. This class of drugs usually is not considered a first or even second line of therapy for BP control. Have you tried others before the Atacand?

Was wondering why your doctor, given that the Atacand wasn't *quite* doing the job, switched you to Cardura instead of keeping you on the Atacand (which, as an ARB has so few side effects in general) and adding a non-sulfa diuretic to THAT regimen? Can't figure out why he/she considered the alpha.

Unless you have something like benign prostate enlargement, (presuming you are a man!), cholesterol problems or diabetes, most doctors prescribe other classes of meds way before the alphas. BUT if you have any of the above problems , Cardura and Alphas are very beneficial.

However, the BP lowering effects of the alphas alone are modest...that's why your doc is thinking of adding the diuretic later.

It sounds like his step-up approach and starting off slowly at a low does at this point is perfect.

Bottom line though is, that whatever regimen controls your BP and doesn't have intolerable side effects and isn't contraindicated because of other health issues, go with it!

zuzu xxx

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Tick Tock
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From:USA
Registered: Aug 2003

posted 08-21-2003 12:47 PM     Click Here to See the Profile for Tick Tock     Edit/Delete Message   Reply w/Quote
Thanks for the reply zuzu! I am still on 32mg/day of Atacand in addition to the Cardura. I think my PCP plans to have me on all 3 - Atacand, Cardura and a potassium-sparing (non-sulfa) diuretic.

She indicated that the diuretic is quite mild compared to HCT, etc. I think that's why she has the Cardura too. We discussed which to add next - the alpha or the diuretic. She said that I have to start a regular blood-monitoring plan. I have had to have a bunch of blood work lately and I probably indirectly steered her to start with the Cardura (alpha) first so I can defer starting the blood testing.

Also, I am staying on the Atacand because I also suffer from migraines and that has really helped as a preventative at the 32mg dose. My migraines are down to 2-3/month from 8-10/month.

So, I guess what feedback I'm looking for from people here is how have alpha blockers worked/not worked and secondly, is anyone on a potassium sparing diurectic and if so, which one(s) and how have they worked.

Thanks again!

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zuzu8
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From: California, U.S.A.
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posted 08-22-2003 12:01 PM     Click Here to See the Profile for zuzu8     Edit/Delete Message   Reply w/Quote
Tick Tock- I made a typo....I didn't mean to ask why your doc "switched" you to Cardura.
My question was, why add the Cardura to the Atacand, instead of simply adding a diuretic to the Atacand to see if that combo works, hopefully to avoid 3 meds ?

A combo of ARB and diuretic is much more widely tried than ARB and alpha.....

Did I misread your post? Sorry if you explained this and I missed it.....
zuzu xxx


[This message has been edited by zuzu8 (edited 08-22-2003).]

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Tick Tock
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From:USA
Registered: Aug 2003

posted 08-22-2003 02:54 PM     Click Here to See the Profile for Tick Tock     Edit/Delete Message   Reply w/Quote
zuzu - at this point, it's theoretical... that said, I can't take the thiazides because of the sulfa allergy, my PCP says the loop diuretics for BP are rarely used anymore because of the side effects. Also, the loops, except for Edecrin have the sulfa problem too. That leaves the potassium sparing class. The one she wants to use (I can't recall which one now - I have med confusion LOL) is very mild and she doesn't think that it alone will be enough to lower my BP enough. So, that's the reason for the alpha blocker (Cardura). She did want to start the diuretic first then add the alpha but at my request (due to the blood monitoring) she just started them in reverse order. I have another appt the first week in Sept. and expect that she'll increase the Cardura since I am noticing some, but not enough effect (down to ~145/92 from 150/100) at the 1mg/day dose. Or, may just add the diuretic.

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zuzu8
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From: California, U.S.A.
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posted 08-22-2003 09:10 PM     Click Here to See the Profile for zuzu8     Edit/Delete Message   Reply w/Quote

Okay...got it straight now...Let us know how you do after your appt. (or before ...or WHENEVER!)...

zuzu xx

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Tick Tock
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From:USA
Registered: Aug 2003

posted 09-09-2003 01:22 AM     Click Here to See the Profile for Tick Tock     Edit/Delete Message   Reply w/Quote
Update - had follow up appt w/PCP. Plan to titrate the Cardura up by 1mg/week up to 8mg/day (less if control is reached before 8mg). I started on 2mg last Thursday and had a bad migraine from Friday p.m. until Sunday night. BP's about the same so far. Headache has been ok since last night.

Also, took a 24hr urine coritsol test. My serum cortisol test was abnormal. I don't expect the more accurate urine test to come back abnormal, but that should sure explain some things if it does.

Stay tuned...

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