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Re: Phospholipids -biochemical point of view

Re: Phospholipids -biochemical point of view

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Posted by Alexandre-H. on December 14, 2000 at 22:25:56:

In Reply to: Phospholipids posted by Peg on December 05, 2000 at 13:42:41:

: I would like to know more about phosphlipids. What is it, and where can I find supplements with phospholipids? Thank you.

There are three major kinds of lipids in living organisms, one of theme are glycerophosphoslipids or phospholipids if you will. Althought triacylglycerols are the most abundant type of lipids in mammals on the basis of weight, they are not structural components of biomembranes because they are not amphipathic and therefore do not form lipid bilayers (amphipatic, means that the molecule is hydrophilic (loves water)and hydrophobic (hates water) at the same time). Biomembranes (wich are the walls of your cell and organelles(inside the cells) consists usually for the most part of phospholipids( usual phospholipids...there are other more complex form of them), which are made of three types of molecules 1 ( two fatty acyl groups) 2 ( 1 glycerol ) and 3 ( a phosphate group wich provides the hydrophilic caracteristic).
So a phospholipid looks like a bubble with two long chains attached.
Technically, the are not fat lipids...even though they have two fatty acyl chains attached to them, fat lipids (even if fat and lipids are synonymous in any scientific language...) are triacyglycerol...they have one glycerol molecule and three fatty acyl chains...they are totally hydrophobic...that is why fat makes droplets on water, it sticks together, it does not dissolve in water. In adipocytes (fat cells), you find many of these fat droplets.

Anyways, we have to understand that when we eat, food is catabolised (cut in pieces) at the molecular level. Phospholipid eaten...in every damn thing...(it's cellular bricks...every thing living is made of cell...every cell surrended by phospholipid) is destroyed in its three components and then reattached, depending of cellular needs. In the Smooth Endoplasmic Reticulum (near the nucleus)(a cell organelle), cell membrane is synthesised as a secretory vesicule and goes through a secretory pathway and and up in the cellular membrane. It is also in the S.E.R that pospholipids are synthesised ( in 3 steps.)

So in the end, there is really no use of taking a supplement of PL, since they are in everything we eat, not in small amount either.

It is in the same view that protein stacks are a bit of a knock off, for the average Joe without university or end of high school education in biology or (in what concerns us biochemistry), Whey protein, for example, is the top source of amino acids...found nowhere in the world...except in tuna, chicken, beef, pork, veal, beans. What's more, it usually contain the same amount of protein as a can of tuna ( in water...no fat)...it is useful for convienience, not biochemically speaking...you don't have tune breath in the end (yet, I have witnesse and been an author of the stench produced by some protein shakes...really disgusting). These cannot have more than the 20 amino acids that exists and no more than the 8 essentials (well, 7.5 considering human failings...we produce, but not enough)
(strangely, glutamine is not one of the essantial a.a. your body produces accordingly to it's needs (we have the genes coding for it's formation)
All these a.a. are present in any form of meat or even in (carefully planed vegetarian diet).

People should consider educating themselves on metabolic processes before spending money on boosters and supplements ( as a rule, people can tell themselves that if the booster is legal, it does nothing...the ephedrine-cafein-aspirin stack works well, it has a good,well understood biochemical functionning, but it is no longer legal in canada, and in many states in the US. They even take it out of medications that used it and replaced it with pseudoephedrine. (wich is far less potent among other things.)For those of you who use it, it as been evaluated that lower doses maintain the thermogenic effect...(lipolysis, and ...)


Stuff like creatine monohydrate leads to water retention, muscle full, which stops after use. and can cause liver and renal damage. (you've all heard this before...if your using it, you'll still be using it anyways)

This is far out from the scope of the PL question but it has been bothering me for a long time now.

In the hope that the first part answered your question about what are PL and where you can find them...(anywhere). For the rest, I am sorry...:-)

Alexandre-H. Dandavino
Biomedical Sciences student at the University of Montreal, Canada.

PS: Any book on biochemistry (introduction or principles ) contains all these information about macromolecules and metabolisms.



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