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Posted by beau on August 16, 2000 at 13:20:08:

In Reply to: RA and Diabetic posted by Dedra on August 12, 2000 at 02:17:34:

: I have had RA for 5 years and have been diabetic for 14 years. I was wondering if anyone else had this combo. Also I have had to stop taking Plaquinel due to side affects(deposits on the retna). My doctor wants to start me on methotrexate. The thought of taking methotrexate scares me deeply. I would appreciate any input. I am 29 and other than this stuff, pretty healthy.

I am also a diabetic with RA. Methotrexate is not any more scary to me than many other RA drugs. There is the potential for mouth ulcers, nausea, and fatigue which can be all or partly controlled by adding folic acid to the mix. The potential for liver damage and lung problems is more scary of course, but monthly blood work and monitoring by your rheumatologist can usually handle any problem that arises, while it is still reversible, as far as liver trouble goes. The lung problem potential, by far the worst worry, in my view, can be controlled too, if the patient and the doctor are vigilant. Lung Xrays and pulmonary tests/exams before starting methotrexate, and regular follow up tests/exams/Xrays will likely show any lung disease in early stages and use of methotrexate can be promptly suspended. I personally don't like methotrexate, but it is an effective RA drug for many people. We must remember that there are not that many drugs available to us that will positively help in treating our disease. Methotrexate "could" be the most effective drug for you. If not, it's easy enough to stop using it and move on to another..., beau

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