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Posted by Roberta Tehan on November 21, 2000 at 05:29:51:

In Reply to: Re: Pepcid AC posted by his dad on October 18, 2000 at 06:08:14:

My mother who has multi infarct dementia with lack of impulse control and has duodenal ulcers
is now using Pepcid AC three times a day. I have noticed an improvement in her behavior, most
specifically she has much better impulse control. Anyone out in cyber space notice improvements
in behavior control whether it be in autistic children or in dementia patients? Please reply. Thanks.
Note: a Medical Journal abstract is enclosed below.

: Gastrointestinal abnormalities in children with autistic disorder.

: Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT

: Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA.

: OBJECTIVES: Our aim was to evaluate the structure and function of the upper gastrointestinal tract in a group of patients with
: autism who had gastrointestinal symptoms. STUDY DESIGN: Thirty-six children (age: 5.7 +/- 2 years, mean +/- SD) with autistic
: disorder underwent upper gastrointestinal endoscopy with biopsies, intestinal and pancreatic enzyme analyses, and bacterial and
: fungal cultures. The most frequent gastrointestinal complaints were chronic diarrhea, gaseousness, and abdominal discomfort and
: distension. RESULTS: Histologic examination in these 36 children revealed grade I or II reflux esophagitis in 25 (69.4%), chronic
: gastritis in 15, and chronic duodenitis in 24. The number of Paneth's cells in the duodenal crypts was significantly elevated in autistic
: children compared with non-autistic control subjects. Low intestinal carbohydrate digestive enzyme activity was reported in 21
: children (58.3%), although there was no abnormality found in pancreatic function. Seventy-five percent of the autistic children
: (27/36) had an increased pancreatico-biliary fluid output after intravenous secretin administration. Nineteen of the 21 patients with
: diarrhea had significantly higher fluid output than those without diarrhea. CONCLUSIONS: Unrecognized gastrointestinal disorders,
: especially reflux esophagitis and disaccharide malabsorption, may contribute to the behavioral problems of the non-verbal autistic
: patients. The observed increase in pancreatico-biliary secretion after secretin infusion suggests an upregulation of secretin receptors
: in the pancreas and liver. Further studies are required to determine the possible association between the brain and gastrointestinal
: dysfunctions in children with autistic disorder.

: Comments:
: Comment in: J Pediatr 1999 Nov;135(5):533-5

: : I've heard about using Pepcid AC with autistic children. How does this work, has anyone tried it, and have they seen good results?

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