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Posted by Margaret. on September 08, 2000 at 17:06:57:

Vijendra K. Singh, Ph.D.
Department of Biology & Biotechnology Center
Utah State University, UMC 4700
Logan, Utah 84322

Today, I will be speaking about the autoimmunity aspect of vaccines in autism, a medical condition
that has been largely ignored by the medical community and federal government for a very long time
and yet the incidence of autism is increasing at an alarming rate. An estimated one-half of a million
Americans, mainly children, and millions more worldwide are known to suffer from autism, a
heart-rending disorder that severely impairs higher brain functions: social interaction,
communication, language, imagination and cognition. The disorder is a life-long mental disability
with devastating consequences for both the patient and his/her family. Thus the financial burden is
huge for the families who care for children with autism.

Autism is an idiopathic brain disorder, which simply means that the etiology of the disorder is not
known. And there is no single, clear-cut cause for autism. Causally speaking, I tend to think that
autism is a complex disorder, in which autoimmunity to brain plays a key role. Today, in
spite of virtually no funding available, autoimmunity is the most extensively investigated
topic of research in autism. This is by and large due to the fact that autoimmunity is the prime
target of therapy that has proven to be quite effective in ameliorating autistic characteristics. Thus
the autoimmunity research, unlike the genetic research, has already significantly improved the health
and welfare of individuals with autistic disorder. I have recently coined a term "Autoimmune Autism
(AA)" to refer to a subset of autism that has autoimmune etiology. Moreover, there are scientific
reasons to think that this subset may indeed be a result of vaccine injuries to children who display
autistic regression.

Autoimmunity is an abnormal reaction immune reaction, in which the immune system becomes
primed to react against body organs. It's a mosaic of highly complicated interactions and networking
between cells and molecules of the immune system. The body makes autoantibodies against itself,
resulting in damage to tissues and organs. The "autoimmune" response is what happens in
autoimmune diseases such as lupus, and my research showed that a similar response my account
for the brain abnormalities found in people with autism.

Autoimmune diseases are identified and characterized by many factors. The hallmark is the
"organ-specific autoantibodies" that have also been identified in people with autistic disorder. To
that end, I have recently summarized laboratory data of approximately 400 cases (autistic and
controls) and found that up to 80% of autistic children have autoantibodies to specific brain
structures, in particular a brain protein known as myelin basic protein (MBP) of the myelin sheath, a
fatty coating that insulates nerve fibers and absolutely essential for higher brain functions. These
autoantibodies are present quite frequently (65-85%) in autistic children, but only rarely (0-5%) in
normal children and other disease controls. Accordingly, I postulated that autism involves a specific
autoimmune response to MBP -- an immune assault that impairs myelin development in the
developing brain, thereby modifying the nerve cell functions of the brain. Ultimately, by way of
impaired wiring diagram in the brain, this results into autism.

Autoimmunity is commonly triggered by environmental exposures such as viral infections. Virus
serology (or virus antibodies) is an excellent tool for studying virus infections in disease states.
However, until recently, such studies had not been performed for autism. Because of my ongoing
research, I became interested in examining a virus link with autoimmunity in autism. I recently raised
two specific questions: (1) Does autistic children have a hyperimmune response (or increase of
antibodies) for a specific virus? (2) Is there a relationship between virus antibodies and brain
autoantibodies in autism? I conducted a carefully designed study to address these two questions.
Succinctly, I made two very important observations: first, there was indeed a hyperimmune response
to a virus and it was specifically for the measles virus (MV), but not for the other viruses tested
[human herpesvirus-6 (HHV-6), rubella virus (RV), and cytomegalovirus (CMV)]; and secondly, there
was an association between measles virus antibodies and MBP autoantibodies (i.e., the higher the
measles virus antibody level the greater the chance of brain autoantibody). Few months earlier in the
same year (February, 1998), I had already found that many autistic children had antibodies to a
specific protein of the measles-mumps-rubella (MMR) vaccine (MMR vaccine preparation). These
viral antibodies were also related to positive titers of brain MBP autoantibodies. This was most
probably the first laboratory-based evidence to link measles virus and/or MMR vaccine to
autoimmunity in children with autism. Collectively, these observations led me to speculate
that autism may be caused by a measles- or MMR vaccine-induced autoimmune response.
Unfortunately, due to lack of funding, I have not been able to extend this research and the progress
has been hampered.

As I made scientific presentation of my initial findings, a vaccine-autism connection became even
more apparent. I compiled a nonscientific, anecdotal survey of vaccine-injured children with "autistic
regression" or autistic disorder, as reported by families. Surprisingly, up to 93% of the reported
cases had autistic symptoms shortly after vaccinations (52% post-MMR, 33% post-DPT, and 8%
post-MMR and/or post-DPT). The remaining 7% of the reported cases were not linked to any
vaccination at all. Indeed, if these numbers are reproducible, the data will lead to inescapable
conclusion that these vaccines can potentially cause autoimmunity in autism. Quite
candidly, this will not be first time that a vaccine has been linked to a disease or disorder. There is
quite a bit of literature linking vaccines to autoimmune diseases. Furthermore, an epidemiological
study just published in JAMA (March 8th issue) described "extraimmunization" amongst American
children and considered it to be a contributing factor for the adverse effects of the vaccines. And I
think the vaccines and autism connection is no exception to these adverse effects.

In summary, the rapidly accumulating evidence strongly implicates autoimmunity in
autism, which in many may result from a vaccine injury. There is a possibility of an atypical
measles infection in autism, but the evidence also suggests a MMR vaccine infection.
Without any reservation, I would strongly recommend that this Congressional Committee reviews all
the information in bipartisanship, and explore the possibility that drug companies never
properly evaluated the safety of vaccines in the first place. If this indeed were true then it
becomes imperative that we as a society must pay an immediate attention to this problem;
otherwise, an epidemic of autism is a real good possibility. There should be no mistaking about it
because autism is on a sharp rise and vaccinations, especially the extraimmunization, could
potentially explain this rise. The onset of autism (or autistic regression) post-immunization
should no longer be regarded as merely a coincidence with the timing of the vaccinations,
as our federal health officials continue to do. We must find new ways to curve adverse
effects of vaccines, including autism. Considering a population of 500,000 cases of autism in
the United States, the autoimmunity research, but not the genetic research, has already had a great
impact on the health and welfare of autistic people. Since brain autoimmunity is found in up to 85%
of cases, it can potentially help an estimated 425,000 Americans. Indeed, many of them are already
reaping the benefits of the experimental autoimmune therapy. Thus there is an urgent need to
promote autoimmunity research in autism. This recommendation is in contrast to the opinions held
by the directors of the federal agencies and major private foundations (Cure Autism Now and
National Alliance for Autism Research) who are erroneously committed themselves to fund genetic
research only. Finally, I urge the Government Reform Committee to provide leadership for new
solutions to the existing problems surrounding autism research, and request the Committee
Members to be visionary and offer new hope to the people with autism -- The essence of life is to

Committee on Government Reform
2157 Rayburn House Office Building
Washington, DC 20515 ∑ (202) 225-5074

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