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Posted by Nancy on September 19, 2000 at 22:44:14:

In Reply to: Wakefield et al " Enterocolitis in children with developmental disorders" American Journal of Gastroenterology posted by Margaret on September 19, 2000 at 17:52:00:

: American Journal of Gastroenterology, September, 2000

: Original Contribution September 2000 Volume 95, Number 9 Pages 2285-2295

: A. J. Wakefield, F.R.C.S.,a,b A. Anthony, M.Sc., Ph.D., M.B.B.S.,b S. H. Murch, Ph.D., F.R.C.P., F.R.C.P.C.H.,b
: M. Thomson, MB.ChB., M.R.C.P., F.R.C.P.C.H.,c S. M. Montgomery, Ph.D.,c S. Davies, M.R.C.Path.,b J. J.
: O'Leary, M.D., D.Phil., M.R.C.Path.,b M. Berelowitz, F.R.C.Psych.,e and J. A. Walker-Smith, M.D., F.R.C.P.,
: F.R.A.C.P., F.R.C.P.C.H.d

: OBJECTIVE: Intestinal pathology, i.e., ileocolonic lymphoid nodular hyperplasia (LNH) and mucosal
: inflammation, has been described in children with developmental disorders. This study describes some of the
: endoscopic and pathological characteristics in a group of children with developmental disorders (affected
: children) that are associated with behavioral regression and bowel symptoms, and compares them with
: pediatric controls. METHODS: Ileocolonoscopy and biopsy were performed on 60 affected children (median
: age 6 yr, range 3-16; 53 male). Developmental diagnoses were autism (50 patients), Asperger's syndrome
: (five), disintegrative disorder (two), attention deficit hyperactivity disorder (ADHD) (one), schizophrenia (one),
: and dyslexia (one). Severity of ileal LNH was graded (0-3) in both affected children and 37 developmentally
: normal controls (median age 11 yr, range 2-13 yr) who were investigated for possible inflammatory bowel
: disease (IBD). Tissue sections were reviewed by three pathologists and scored on a standard proforma. Data
: were compared with ileocolonic biopsies from 22 histologically normal children (controls) and 20 children with
: ulcerative colitis (UC), scored in an identical manner. Gut pathogens were sought routinely. RESULTS: Ileal LNH
: was present in 54 of 58 (93%) affected children and in five of 35 (14.3%) controls (p < 0.001). Colonic LNH was
: present in 18 of 60 (30%) affected children and in two of 37 (5.4%) controls (p < 0.01). Histologically, reactive
: follicular hyperplasia was present in 46 of 52 (88.5%) ileal biopsies from affected children and in four of 14
: (29%) with UC, but not in non-IBD controls (p < 0.01). Active ileitis was present in four of 51 (8%) affected
: children but not in controls. Chronic colitis was identified in 53 of 60 (88%) affected children compared with one
: of 22 (4.5%) controls and in 20 of 20 (100%) with UC. Scores of frequency and severity of inflammation were
: significantly greater in both affected children and those with UC, compared with controls (p < 0.001).
: CONCLUSIONS: A new variant of inflammatory bowel disease is present in this group of children with
: developmental disorders. Cite this article as: . Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery
: SM, Davies S, O'Leary JJ, Phil D, Berelowitz M and Walker-Smith JA. Enterocolitis in Children With
: Developmental Disorders. Am J Gastroenterol September;95:2285-2295. aUniversity Departments of
: Medicine, bHistopathology, cPaediatric Gastroenterology, and dPaediatric Psychiatry, Royal Free and
: eUniversity College Medical School, Royal Free Campus, London, United Kingdom, and University Department
: of Pathology, Coombe Women's Hospital and Trinity College, Dublin, Eire

I know my daughter started Autistic behavior after Lyme Disease but since then she has never
had a solid BM. Is this all related?

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