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Posted by Dan on September 29, 2000 at 14:47:30:

In Reply to: Re: My 4 year old autistic son is starving himself. posted by hisdad on September 28, 2000 at 19:33:28:

Thank you. I will check into esophagitis and endoscopy and colonoscopy . He has been gluten-casein free for about a year now as well as many supplements. We are currently giving him something for minimizing gas. He is improving modestly but not enough. We have to coax him to eat and drink. Interestingly, he has tried a few new food items. This is extremely rare for him. He is the ultimate picky eater, but he is not even eating his preferred foods. Even more troubling is his refusal to drink and also the panic he displays when we attempt to nurish him. He seems out of danger for now but we are all a bit edgy.

from Florida,

: Dan,

: Does he crave certain foods (like cheese and bread) that you know you can't give him due to beahavioral problems? Visit for gluten-casein free diet stuff. Another thing, he may have esophagitis - which is a chronic condition among autistics - it may just hurt too much to swallow. There are papers written on it - see below.

: If you haven't done an endoscopy and a colonoscopy (colon pollips are also quite common) you should do it ASAP. We did it since we had the same symptoms you do, like exactly, echolalia and all - and found he had esophagitis. Put him on prilosec (antiacid) and gfcf diet and we have seen phenonemnal improvements. He was 4 now five and doing great!! He feels better, eats more, weight accelerating. Please look into gluten/casein free diet, and endoscopy and colonoscopy and doing gluten and casein blood tests (alletess labs in MA(800-2255404). They tested for gluten and casein antibodies to
: determine whether a gfcf diet would help. It indicated it would. You can arrange it yourselves through your doctor. Call Allettess labs ( others do the same thing) and they will send you packing stuff.

: hisdad

: : I don't know what to do. We can not communicate with him as he is only somewhat echolalic. He screems at the sight of food and is refusing to drink as well. He gets bearly enough to stay alive. My wife and I are very worried and don't know what caused this behavior. What can we do?

: Gastrointestinal abnormalities in children with autistic disorder [see
: comments]
: Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT
: J Pediatr 1999 Nov 135:5 559-63


: :
: J Pediatr . Volume 135 . Issue 5

: :
: MEDLINE, full MEDLINE, related records

: Abstract

: OBJECTIVES: Our aim was to evaluate the structure and function of the upper
: gastrointestinal tract in a group of patients with autism who had
: gastrointestinal symptoms. STUDY DESIGN: Thirty-six children (age: 5.7 +/- 2
: years, mean +/- SD) with autistic disorder underwent upper gastrointestinal
: endoscopy with biopsies, intestinal and pancreatic enzyme analyses, and
: bacterial and fungal cultures. The most frequent gastrointestinal complaints
: were chronic diarrhea, gaseousness, and abdominal discomfort and distension.
: RESULTS: Histologic examination in these 36 children revealed grade I or II
: reflux esophagitis in 25 (69.4%), chronic gastritis in 15, and chronic
: duodenitis in 24. The number of Paneth's cells in the duodenal crypts was
: significantly elevated in autistic children compared with non-autistic
: control subjects. Low intestinal carbohydrate digestive enzyme activity was
: reported in 21 children (58.3%), although there was no abnormality found in
: pancreatic function. Seventy-five percent of the autistic children (27/36)
: had an increased pancreatico-biliary fluid output after intravenous secretin
: administration. Nineteen of the 21 patients with diarrhea had significantly
: higher fluid output than those without diarrhea. CONCLUSIONS: Unrecognized
: gastrointestinal disorders, especially reflux esophagitis and disaccharide
: malabsorption, may contribute to the behavioral problems of the non-verbal
: autistic patients. The observed increase in pancreatico-biliary secretion
: after secretin infusion suggests an upregulation of secretin receptors in
: the pancreas and liver. Further studies are required to determine the
: possible association between the brain and gastrointestinal dysfunctions in
: children with autistic disorder.

: MeSH

: Autistic Disorder (*CO/EP), Child, Preschool, Diarrhea (CO/EP), Digestive
: System (ME), Disaccharides (ME), Duodenitis (CO/EP), Duodenum (PA),
: Esophagitis, Peptic (CO/EP), Female, Gastrointestinal Diseases (CO/*EP),
: Human, Malabsorption Syndromes (CO/EP), Male, Paneth Cells (PA), Prevalence,
: Receptors, Gastrointestinal Hormone (ME), Secretin (SE), Support, Non-U.S.
: Gov't, Up-Regulation (Physiology)

: Author Address

: Department of Pediatrics, University of Maryland School of Medicine,
: Baltimore, USA.

: CAS Registry Number (Substance Name)

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