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Old 08-27-2010, 09:02 PM   #1
Join Date: Aug 2010
Location: NJ
Posts: 2
Feraferia HB User
Anti-Chromatin Antibodies & Lupus

Hi All,

I'm a 26 year old female who has been experiencing achy joints and a weak feeling in my legs for the past few weeks. I went to the doctor who ordered bloodwork, which came back normal except for the following:

WBC 11.0 (Normal is 4-10.5)
ANA Direct Positive - There was no number provided, it just said Positive
Anti-Chromatin Antibodies - 1.8

I was negative for the following antibodies: Anti-DNA (DS) Ab Qn, RNP, Smith, Antischleroderma 70, Sjogren's Anti-SS-A, Sjogren's Anti SS-B, Anti-Jo-1 and Anti-Centromere B.

My PCP recommended a see a rheumatologist and I have an appointment but after some research, I've found that anti-chromatin antibodies are becoming known as a good diagnostic tool for SLE as they don't show up in healthy people or in other diseases. Does anyone know if this is true? Also, does anyone know if these antibodies show up often as a false positive?

I know people who do not have SLE can have a positive ANA but I'm not finding too much info about anti-chromatin antibodies. At this point, I'm wondering if I do have SLE, if it could be something else or if it could be a false positive. If someone has any guidance I would appreciate it.



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