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Minocycline pigment changes

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Old 12-06-2003, 08:46 AM   #1
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Join Date: Oct 2003
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FadeToKeloid HB User
Minocycline pigment changes

lately my minocycline dosage of 200mg which i have been taking for a 1 year and 7 months has started to make my pimples just turn into dark purple marks on my skin without ever even forming a white head. They stay for ever and never seem to go away in the entire time ive been taking it. Im started to get pretty worried. I asked my derm and he said "i dont know" no joke which just made me all the more nervous. I take vitamin c everyday(which i heard helps) so i dont see why this is happening. Has this happened to anyone else?

Last edited by FadeToKeloid; 12-06-2003 at 08:53 AM.

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Old 12-06-2003, 11:14 AM   #2
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Join Date: Dec 2003
Posts: 35
rippey HB User
Re: Minocycline pigment changes

Here's some info I found on the web. Do a search on MSN for "minocycline blue skin" and this will come up. Sounds like you have the first category of pigmentation. The longer you use the drug, the more likely and obvious the pigment changes become. Trust me, i've experienced it.

Langevitz, et al - Minocycline in Rheumatoid Arthritis; Isr. J. Med Sci 1996;32:327-330
"We also observed skin hyperpigmentation in about one third of our patients as a late complication of the therapy.

Minocycline related hyperpigmentation of the skin is a well known complication of this agent and can be subdivided into three categories. The first is characterized by dark blue-black macules localized at sites of cutaneous inflammation. The pigment found in those areas is hemosiderin or an iron-containing substance. The second type is a more diffuse hyperpigmentation, predominantly on the lower extremities and on areas exposed to sunlight. The skin in this type of hyperpigmentation contains melanin. The third form of minocycline-induced hyperpigmentation is the "muddy skin syndrome" - a dark brown-gray discoloration of the skin generalized over the body, less prominent in non exposed areas.

The high incidence of skin hyperpigmentation in our group of patients is probably due to the longer followup period than that in other groups, and to sun exposure."

The article ends with "Based on our more than 5 years experience with this drug and on the three double-blind studies, it seems that minocycline is an effective and adequately tolerated drug in patients with rheumatoid arthritis, including those who did not respond to previous DMARD therapy."

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