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Allergy testing for Drug Allergies?????

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Old 01-29-2005, 09:06 PM   #1
Junior Member
Join Date: Jan 2005
Location: NW US
Posts: 25
PJ59 HB User
Smile Allergy testing for Drug Allergies?????

Hi,My internist has recommended that I go see an allergy specialist for my allergies.I am having a problem with extreme sensitivity to all prescription & otc drugs that I have used recently from NSAIDS,antihistamines,lidocaine,& others.I have a slight hay fever problem & I know exactly what I am allergic to in that department.But how can I be tested for drug allergies? I haven't been able to find much info on this subject.Thanks in advance!

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Old 01-30-2005, 10:34 AM   #2
Join Date: Jan 2005
Location: Central NY
Posts: 91
rck213 HB User
Re: Allergy testing for Drug Allergies?????

I just went the same route as you because there hasn't been a BP med I haven't reacted to. I have multiple drug allergies and sensitivities. In 1988 I was diagnosed with angioedema from drug reactions.
I managed to avoid all meds for many years but recently have developed osteoarthritis in the knee and my BP isn't staying controlled by diet and exercise plus vitamin supplements alone.

I went to a conventional allergist who told me there was no testing for drugs available except for Penicillin and at this time that isn't even possible due to a shortage of the extract used in this test.

He wasn't very sympathetic, questioning some of my claims to reactions even though they are well documented in my history. I have been through elimination diets and immunotherapy for inhaled allergens, I am an RN and have a very good understanding of my allergies.

I haven't been able to find much about multiple med reactions either other than reading an article in a general health magazine that there are people out there who seem to be "medication reactors" with mutiple medication reactions and sensitivities that sometimes are dose related.

I would like to have more info on this too, so if you find any please pass it on

Last edited by rck213; 01-30-2005 at 10:36 AM.

Old 01-30-2005, 11:10 AM   #3
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jhmitch HB User
Smile Re: Allergy testing for Drug Allergies?????

Originally Posted by PJ59
My internist has recommended that I go see an allergy specialist for my allergies.I am having a problem with extreme sensitivity to all prescription & otc drugs that I have used recently from NSAIDS,antihistamines,lidocaine,& others...But how can I be tested for drug allergies? I haven't been able to find much info on this subject.Thanks in advance!
Hi PJ59!

That is a good question, and one I wish I could answer, as I also react to aspirin, NSAIDS, a number of antibiotics, and codeine.

According to the little I've read on the subject, there aren't a whole lot of tests available for specific drug allergies. Proteins like insulin, penicillin, and some products used in the health care field, can (supposedly) be tested by determining the presence of Ige antibodies, but my allergist said we'd probably have to go the route of eliminating certain medications, then reintroducing them (gradually) to see which one triggers a reaction.

Hopefully, when you go to an allergist, you two can work together on isolating what is causing your reactions.

What makes it a bit more difficult is that the reaction time for drug allergies can be anywhere from almost immediate to as long as two weeks after the drug was taken. Usually, drugs that have been taken for a number of weeks prior to the allergic reactions are less likely to be suspected of triggering a reaction - though some of them certainly do.

rck213 - I'm sorry your allergist was so questioning about the reality of your situation. No patient needs to be given that sort of attitude! I heard the same thing, too, when I was hospitalized a year ago: I was assured I wouldn't react to an injection of a new antibiotic (I did - while in surgery ).

Someone (on these boards) who has already been through this process probably knows a lot more about what can be done for medication allergies than I do and I hope there are additional answers to your question.

Wishing you some answers and relief to your drug reactions!

"It is more about the journey... than the destination"

Last edited by jhmitch; 01-30-2005 at 08:08 PM.

Old 01-30-2005, 06:06 PM   #4
Join Date: Jan 2005
Posts: 9
junkyarddawg HB User
Re: Allergy testing for Drug Allergies?????

I also have this problem. no matter what i take from vitamins to antibiotics i have a reaction. so if anyone finds anything on this please let me know, i am at my whits end. i think my dr. thinks i am just nuts.

Old 01-30-2005, 08:36 PM   #5
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PJ59 HB User
Talking Re: Allergy testing for Drug Allergies?????

Hi to all who responded! Has anyone had any experience with the brand new -
DNA Drug Reaction Profile Blood Testing by Genelex Labs? Think it was released approx 1 month ago. It's expensive but may be worth the cost if accurate. Not sure if I can post the site where I found it. Let me know if I can as am new to this and haven't gotten all the rules down yet! And thanks for all the input!!

Old 02-01-2005, 04:34 PM   #6
Join Date: Jun 2004
Location: PA
Posts: 128
hoffta HB User
Re: Allergy testing for Drug Allergies?????

I too have allergies to many drugs. I broke out in a terrible rash from Prednisone and the docs all said that there was no way I could be allergic to prednisone because it was like being allergic to yourself. What they came up with was that I was allergic to the binding agent in the prednisone.

I am wondering now though if it is something they use in generic drugs that I am allergic to. I am allergic to Levoquin, Vicodin, Oxycontin, Oxycodone, Vioxx and a few others.

If anyone finds that there is a way to test for drug allergies please let me know. My docs assume since I get a rash and itch really bad from these drugs that I am allergic.

Old 02-19-2005, 09:08 AM   #7
Join Date: Sep 2003
Posts: 399
suggi HB User
Re: Allergy testing for Drug Allergies?????

Hi Hoffta
I too am allergic to almost everything drug related. I have a 2 page allergy list and am afraid if I ever have to go to the hospital they will do me in. No one can keep reading that whole list. It goes from penicillin, sulfa, tetracycline, nuclear medicine dye (had a bone scan), flu shot, pneumonia shot, IVP dye, Flagyl, antifungals i.e. monistat, etc., nitrofuorintoin, Tilade inhaler, servevent inhaler asacol (for Crohn's), certain corticosteroids in prednisolone family, neomycin, lanolin, nickel, carba mix (in natural and synthetic rubber - which means latex and nitrile, rubber stoppers in medication vials, ports in IV tubing, catheters, etc, etc.), balsam of peru (In dry socket packing for extracted tooth, etc. etc.) topical sorbitol and polysorbate (also in meds, toothpaste, etc., etc. Erythromycin makes me feel like passing out and Ceclor kills my Crohn's)

Went for allergy testing for oral polysorbate for my meds and allergist used a Prevacid capsule powder. Was OK until the full strength one intradermally. BIG reaction. Luckily my husband was off that day and went with me and they used him as a control and his reaction was worse than mine. In fact, he got cellulitis from it and had to go on Keflex 500 for 10 days. I could never do that because of the Crohn's. Makes me not want any more allergy testing.
Any input back from you would be appreciated as I have severe osteoporosis and a breast cancer survivor and the meds are a problem for me. The Evista I am on now for osteo is not working and afraid to take Fosamax (bad gastirtis/esophagitis/acid reflux on double strength Prevacid and Zantac and still bad). Others not a good candidate for and don't know about reaction.



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