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  • Vitamin B12 deficiency, Pernicious anemia?

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    Old 07-13-2002, 02:17 PM   #1
    jgates
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    Post Vitamin B12 deficiency, Pernicious anemia?

    Dear Members I am new to the board and have found that I share similar symtoms with those of you with pernicious anemia. Has anyone had difficulties in determining a correct diagnosis. I have been through many tests only to find most of them normal. They only tests that were not normal were the B 12 (104) and I had and acid stomach of ph6. My intrisic factor test was normal and the upper GI endoscopy showed a normal atrophy(uncertain if that is a correct term). They x-rayed for Chrons, tested for Wheat allergies and parasites and did a procto. My blood is normal. I have been on B12 injections for about 7 months. I am still very tired and my neck and back are sore. I can only do one thing a day and then have to rest.One of my doctors says that the acid stomach shows the beginnings of pernicious anemia, the other doctor says no, that it is only about intrinsic factor. Is there another way to check for pernicious anemia. Does anyone know about gastric parietal cells? The doctors told me that the Schilling test isn't used any more. Could there be anything else that would cause a B 12 deficiency. I want to know because I am not getting stronger. Thank you so much.
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    Old 07-13-2002, 05:20 PM   #2
    Harry
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    igates,
    I don't know where you live but I would get referred to a blood specialist -- I think they are called Hematologist --- and they specialize in blood problems.

    I think you're stomach is suppose to be acid ----that how we keep germs from attacking us ---no germ known lives in an acid environment. People that have stomach problems are often given proton pump inhibitors that reduce acid levels--- Prilosec, Privised, Nexium and Aciphex are examples.

    I developed anemia by chronic diverticular bleeding in my colon. Half of my colon was removed on March 4, 2002. Since then, I have been doing alot of reading about how to get back to normal.

    God Bless---Harry

    [This message has been edited by Harry (edited 07-13-2002).]

     
    Old 07-13-2002, 06:38 PM   #3
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    Dear Harry, thanks for the post. I will try a hematologist. The doctor thought my stomach was too acid, more acid than normal. I am unsure of the normal ranges. Mine was a Ph6. I really don't have problems with a stomach ache although sometimes I do have an upset stomach.I sure hope you are feeling better and have fun trying to get back to normal. Normal to me I hope is more fun.
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    Old 07-14-2002, 08:47 PM   #4
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    I just found out that a PH of 6 is not acid for your stomach. Does anyone who has pernicious anemia know the PH of their stomach?
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    Old 08-08-2002, 03:03 AM   #5
    SnowyLynne
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    I don't know what my stomach ph is,but I do have Pernisous Enemia.I do not have the intrinsic factor at all.My hubby gives me my B-12 injections,right now every week.......My stomach has been giving me a fit.I have GERD(acid reflux).

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    Old 08-08-2002, 12:16 PM   #6
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    According to a Merck Manual article, gastric Ph is usually low [hypo] in people with pernicious anemia. There's a good article on this condition on a medical site, but you'll have to do a search to access it.

    Achlorhydria Authored by Klaus Radebold, MD, PhD, Research Associate, Department of Surgery, Yale University School of Medicine

     
    Old 08-31-2002, 08:05 PM   #7
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    I have pernicious anemia and acid reflux. your B12 is very low even for a normal person with the intrinsic factor, I think the range is about 250 on up! My B12 was 106 or thereabouts 7 yrs ago. Also pernicious anemia is the end result of gastritis which is what destroys the intrinsic factor. I had a severe bout of gastritis back in '93 ended up in the hospital for a couple days, within 6 months I started showing neurological deficits and it was still a year before I was sent to a neurologists who descovered the B12 def and the neurological problems it caused and which I still have not regained and probably never will. Neurologists also deal with this pernicious as it is a blood disease that messes up the nervous system amoung other things. Every 2 weeks I give my own shots and I rotate, I do my thighs and my hubby does the arms that way I don't get overly sore, been doing this for 7 yrs and still lots of problems, took 3 yrs to just get my level up to 600 with shots every week then. Now we are trying to keep my level above 1000 but I drop real fast and I even take sublingual B12 to keep me stable.

     
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