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  • Pernicious anemia/high Gastrin levels

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    Old 03-04-2012, 06:10 PM   #1
    habbott2001
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    Pernicious anemia/high Gastrin levels

    Hi! Never done a forum before but need some answers. I recently was diagnosed with atrophic gastritis and pernicious anemia. (no intrinsic factor and B12 level was 140) The last blood test they did was gastrin level which came back 3500 (normal is below 100). My first question is, could the high gastrin level be from the pernicious anemia and has anyone ever had a level that high? Second question is what would be the correct treatment for such low B12 levels. My doctor gave me one injection and then only prescribed sublingual b12 3 times a week- to me it doesn't seem aggressive enough and I am still exhausted and have heart palpitations. Any advice would be greatly appreciated. Also, my mother died at the age of 33 to breast cancer so my fear is I carry the BRACA 1 (2) gene. Nervous about my increased risk of stomach and pancreas cancer with the PA and AG.

     
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    Old 03-05-2012, 04:38 AM   #2
    estelle454
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    Re: Pernicious anemia/high Gastrin levels

    pernicious anemia is an auto immune disorder apparently, my dad had it, he had a b12 shot once a month, i have gastritis and have anemia. i think having gastritis, the stomach acid plays havoc with the lining and you lose the intrinsic factor which takes up the b12. That why you have to have it by injection. If ;you take the tablets it does nothing as you have no intrinsic factor. My rhuematologist just told me this last week that pernicous anemia is auto immune. Have you got other auto immune problems, Good luck; hope this helps.

     
    Old 03-25-2012, 02:16 PM   #3
    Dmm27
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    Re: Pernicious anemia/high Gastrin levels

    Hi,
    I am curious to find out how things are going for you and what your treatment has been.

    I am researching for my mom who was also diagnosed with pernicious anemia.

    It started because her gastrin levels tested as high and the first dr. Jumped to conclusions and basically diagnosed her with zolinger ellison which is a very serious condition. The more researching I did, I found out about pernicious anemia and the relation to high gastrin levels. I urged her to get her b12 levels checked. Her levels were of course extremely low and the dr. Gave. Her four rounds of b12 in October. She was then supposed to have her levels checked every 3 months (I assumed she would still be receiving b12 injections as this is clearly what on needs with Pernicious Anemia).

    I just found out yesterday that she has not been receiving b12 injections and because her levels of gastrin are still high and b12 are still low the dr. Is sending her to a specialist for "secretion test" on her stomach. I feel as though all of this has been focused on her high gastrin levels and her pernicious anemia has not been properly dealt with.

    Is my thinking true that had she been receiving b12 injections all of these months her b12 levels would have been higher thus lowering her gastrin levels?

    I feel as though my mom has been given too many incompetent doctors through all of this and her problem is not being properly dealt with!

     
    Old 03-26-2012, 04:19 AM   #4
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    Re: Pernicious anemia/high Gastrin levels

    HI there, I am about to go back to doctor tomorrow. My dad had thyroid }Low} and pernicious anemia which apparently go hand in hand. As my doctor says if you have one auto immune disorder you may get another, I have hashimotos, and apparently sjogrens . The ro what ever that is come up positive. ANA was okay. RF was okay, I have low hemoglobin, low platelets, low white count,. It goes up and down. I have had lots of tests. I have been tested for b12 before but it was okay. Now they have tested it again. Will know more tomorrow. My father had b12 shot once a month, he was 70 when diagnosed. His blood count went down to dangerous level, he was put in hospital and they did tests, they were about to do a bone marrow test, but they discovered the pernicious anemia. I have had a bone marrow biopsy done a few years ago. I had a gastroscopy and they found I had heli-bacter and gastritis and was treated for it. Hope this helps, let me know what happens.

     
    Old 03-28-2012, 11:44 AM   #5
    TraciMac92
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    Re: Pernicious anemia/high Gastrin levels

    Ive had the problem since 2004. My last bloodwork was beginning of March and I finally had normal results. Ive had IV Iron Dextran every 4 to 6 monthes since I crashed and passed out from my levels being so low.
    My 1st IV treatment didn't help. I had to have it repeated 2x more before I could function again. My hematologist started me on monthly B vitamin injections (not just b12) which I give myself at home and still do today. It took 8 yrs for the combo of iron treatments at the cancer center and B vitamin injections to help (the dr was actually surprised that my levels returned to normal).
    I do have absorbation issues that onset from no where. I was a blood/platelets donor my entire adult life until this happened.
    I hope this gets resolved quickly for you. I have great drs and it did take 2 specialist to finally correct the issues with my stomach and iron. I know the entire time I stayed ill and had no energy. It really felt as if I would catch every cold/virus/germ in a 10 mile radius.

     
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    b12 deficiency, gastrin, gastritis, pernicious anemia



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