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  • RA Titer

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    Old 05-14-2019, 06:17 PM   #1
    Bunge
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    RA Titer

    Got diagnosed with RA today.

    Titer number was 1:4

    Very hard finding info on this number that makes sense.

    Is 1:4 worse than 1:80 (for example) or the reverse.

    Can anyone please help me understand?

    Dr. wants me to start prednisone then plaquenil (for life???)

    Should I get second opinion?

    Thx

     
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    Old 05-15-2019, 07:18 AM   #2
    JohnR41
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    Re: RA Titer

    There's no medical cure for Rheumatoid Arthritis. It may be that prednisone and plaquenil will help with the pain and delay deterioration. The point of this treatment is to manage your decline because it doesn't get to the root cause. The reason: RA is a lifestyle (autoimmune) disease.

     
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    Old 05-15-2019, 09:55 AM   #3
    Bunge
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    Re: RA Titer

    Quote:
    Originally Posted by JohnR41 View Post
    There's no medical cure for Rheumatoid Arthritis. It may be that prednisone and plaquenil will help with the pain and delay deterioration. The point of this treatment is to manage your decline because it doesn't get to the root cause. The reason: RA is a lifestyle (autoimmune) disease.
    Thank you.

    Trying to decide whether a 1:4 Titer result warrants risks associated with plaquenil at this stage.

    "A titer is a measure of how much the blood sample can be diluted before RF can no longer be detected. A titer of 1 to 20 (1:20) means that RF can be detected when 1 part of the blood sample is diluted by up to 20 parts of a salt solution (saline). A larger second number means there is more RF in the blood. So a titer of 1 to 80 shows more RF in the blood than a titer of 1 to 20."

     
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    Old 05-15-2019, 10:50 AM   #4
    quincy
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    Re: RA Titer

    RA is definitely an autoimmune disease, and it will be in your DNA structure. It's not caused by anything you have done.

    Do you have any other AI diseases?

    I have a friend with RA, and she uses LDN...low dose naltrexone by rx with good success.

    Worth seeking the info and presenting it to your doctor for a good trial run.

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    Old 05-16-2019, 02:52 AM   #5
    MSNik
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    Re: RA Titer

    Hi there. My mom has RA and I have a different autoimmune disease- but the drugs you mentioned are very standard and a second opinion is probably not needed.
    Prendisone is going to be used when you have a major flare up- it is a steroid which helps take down the inflammation. I know my mom hates being on it because it can cause you to gain weight- but I take it for my autoimmune disease (MS) and do not gain weight...

    You will only be on it when the flare up is bad...

    As of now, Plaquenil for life is probably your best bet, but keep in mind that new drugs come out all the time and its quite possible that your doctor will change your meds if something better comes along. I am also on meds for life.

    As long as you like your doctor, who I assume is a Rheumatologist; you should be in good hands; but this is a life long disease, so make sure you are comfortable with your specialist as you will have a long relationship with him/ her.

    Good luck and welcome to the world of the unknown. Each day can bring something different- eventually you learn to live with it.
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    Old 05-16-2019, 08:30 AM   #6
    Bunge
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    Re: RA Titer

    Thank you for the replies everyone.

    Seems the 1:4 ratio (although hard to find info) is pretty beginning stages.

    Hopefully this means it will be nipped in the bud.

    I live in the Bahamas and there is no rheumatologist on the Island so I am relying on my GP.

    Heís a really smart guy though.

    I am taking precautions and going to Florida to do the eye tests before starting the plaquenil. Want to make sure itís done right and results are safely stored in ďcivilizationĒ.

    Still, so much stress in life. This doesnít help.

    Hopefully, on the meds, I wonít feel like Iíve been hit by a truck every morning I get up, and will be able to resume working out.

     
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    Old 05-16-2019, 08:50 AM   #7
    JohnR41
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    Re: RA Titer

    Quote:
    Originally Posted by Bunge View Post
    Thank you.

    Trying to decide whether a 1:4 Titer result warrants risks associated with plaquenil at this stage.

    "A titer is a measure of how much the blood sample can be diluted before RF can no longer be detected. A titer of 1 to 20 (1:20) means that RF can be detected when 1 part of the blood sample is diluted by up to 20 parts of a salt solution (saline). A larger second number means there is more RF in the blood. So a titer of 1 to 80 shows more RF in the blood than a titer of 1 to 20."
    Sorry, I'm not familiar with that aspect of it and didn't have time to elaborate on what the root cause might be. This is the result of a relatively new discovery and is difficult to research. It seems the internet has not been updated very well; I learned about this from other sources.

    The common term of causation is "leaky gut" which refers to hyperpermeability of the small intestine. If you ask your doctor, it's likely he or she won't know about it. The small intestine has a super thin lining that is especially designed to absorb nutrients but keep out bacteria and undigested proteins. If this lining is damaged and small molecules of undigested protein are allowed to pass through, this is what is thought to lead to autoimmune disease. That's because your immune system will see the undigested protein molecules as invaders and send an attack force. If the protein resembles protein that exists as part of your body, then your immune system may get confused and attack you.

    The next step involves what you would have to do to avoid this problem. In short, it involves a special dietary regimen that will be of benefit to your microbiota or microbiome. Those are the names given for a community of beneficial microorganisms that live in your lower digestive system.

     
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    Old 05-27-2019, 10:59 PM   #8
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    Re: RA Titer

    If I understand the condition correctly, RA occurs when your body starts to create an antibody against its own tissue (ie joints and other tissue).

    For example, I think when you get vaccinated for say measles, your body sees the measles in your blood (in this case a virus), identifies it as a foreign pathogen, then creates an antibody specifically for that pathogen. The anti body attaches to the virus, which then ..i am guessing here...causes white cells to come over and kill the pathogen somehow. Your body retains the memory for how to create this antibody for many many years, often for life. For some vaccines, you need a booster shot a decade or two later. This tells me that for some pathogens, your body loses the ability to remember how to create that antibody, and needs a reminder. Maybe something like this is what happens to some people when their RA goes into remission on its own.

    Anyway, because your body has not created this antibody for your own tissue, it is likely to continue on doing so for many years or decades. This antibody will attack and destroy your joints and other tissue and make you feel very unwell if not treated.

    The strategy the doctors seem to use, if I understand it correctly, is to use drugs called DMARDS, to lower your immune system to the point that it creates fewer of the antibodies that are attacking your joints. If they turn the immune system down too far, you will be defenseless against foreign pathogens and will die, so they have to be careful how far they turn down the immune system. You start out with mild DMARDS (sulfasalazine for example) then proceed on to stronger DMARDS if the milder versions do not work (ie methotrexate). If methotrexate, or a combination of methotrexate with sulfasalazine or plaueinil does not work, then they will move on to Biologics.

    RA is a serious condition. It can shorten your life considerably. However, by treating it aggressively you can stop the damage to your joints and other tissue like organs, and live a normal life.

    I was diagnosed about 6 months ago and currently my RA (or whatever it is), is not under control. I am currently surviving on Medro Dose Packs (prednisone) but the doctor said he may not prescribe any more. I am kind of worried about what is going to happen in 3 days when I run out. Basically before you get into drug induced remission, you have to do what you can to control inflammation and flares. The damage to your joints happens pretty quickly and from what I have read, you want to get this under control fast by treating the condition aggressively.

    Good luck with your condition and please keep us informed.

     
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    Old 06-03-2019, 12:20 PM   #9
    Amanda8664
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    Re: RA Titer

    I have been on Plaquenil for 6 years now. No eye issues to date. There are days that my joints hurt regardless of what meds i am taking. I think you will find a difference pretty quickly. I did anyway. I hope you get some relief!!!!!

     
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    Old 06-03-2019, 05:10 PM   #10
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    Re: RA Titer

    I thought I would provide an update. My doctor wants me to stop all Prednisone or the like for 1 week, let the flare come back, then do blood tests, then I can go back on prednisone. 4 more days to go, so far it has been manageable.

    On another note. I just returned from the ER where I was experiencing some of the worst pain in my life for about 12 hours due to constipation. If you have an autoimmune condition, or take drugs to treat it, and are new to thie process, please be very careful about staying hydrated, eating high fiber foods and heating as healthy as possible.

     
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