I read "The Arthritis Cure" in 1999. (Have a note on a paper in my book with the date on it)
In '99 I was having problems with OA in both knees.
I faithfully began taking Glucosamine with Condroitin plus MSM.
After a year or so I decided it was just trendy nonsense and stopped taking the stuff. They are really not cheap suppliments and I was tired of paying for them.
OPPS. Stopping that was mistake. Knee pain got much worse.
I began once again taking Glucosamine with Condroitin plus MSM faithfully.
Knee pain sensations got better a couple months after restarting.
Since then I have worse knee OA and have developed rather painful OA up my entire spine. During that time I've also developed OsteoPorosis on top of the OsteoArthritis all up my spine. Those combine to create a 10% scolosis (curvature) in my Lumbar spine already.
So from my personal experience I can tell you it definately lessens my OA knee pain and I continue taking it, even, today for that very reason.
..but does NOT stop the OA from becoming physically worse and it defiantly doesn't do a darn thing for my spine.
Does not even lessen pain sensation in my spine.
It HAS made my hair wave oddly and weakened my fingernails (Those are known possible side effects)
Saw a TV news segment this year concerning this. Some medical scientists did a study with a "test group" over a lengthy period. The results were that basically...no, Glucosamine with Condroitin plus MSM has no real physical effect on OA at all, though many of the test group did report less knee pain sensation.
Then I saw a new release condeming the study because it did not take into account the amount of Glucosamine with Condroitin plus MSM needed per the weight of each individual, but rather used standard dosages. Heavier people apparently need more in order to obtain a benifit.
So if it helps lessen your pain, take it.
Be AWARE Condroitin is a big natural BLOOD THINNER.
AVOID Condroitin if you are taking any form of blood thinning medication or an aspirin treatment.
You can get Glucosamine without Condroitin.
The MSM is basically a Sulfer that helps you absorb the other 2.
I can tell you how I lessen the sensations of both the spine and knee pain.
Begin sleeping on your side with a knee contour pillow between your legs just above the knees and a traditional pillow between the legs just below the knees (leaving the sore knees not touching anything).
These pillows have the effect of keeping your skeleton in a more natural less stressful position while you lay there. Less stress on the skeleton means less stress on all the muscles and nerves around the arthritic joints. Less skeletal stress = less pain.
This worked wonders for me in 3 short nights.
I have been useing them every night for over a year now and I am NEVER voluntarily sleeping without them again.
The pillow idea has been a miricle pain relief as far as my spine is concerned.