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    Old 07-09-2008, 07:55 PM   #1
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    what are the side effects of taking methotextrate

    what are the side effects of taking methotextrate

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    Old 07-10-2008, 10:03 PM   #2
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    Re: what are the side effects of taking methotextrate

    I've been taking it for almost 9 years now, 3 pills a week, and all I have is thinning of the hair (yes, I take folic twice a day but I still have thinning). Hope this helps.

    Old 07-28-2008, 11:37 AM   #3
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    Re: what are the side effects of taking methotextrate

    I have only been taking it for two weeks but the main problem that I have had is sores on the tounge. They are like "lie" bumps on the tounge. I have several of them and they are extremely painful. I am still really tired and don't have a lot of energy but I think that is due to the RA and not the medicine. My doc said that it might take six weeks or more to notice a difference in my pain. I hope it works and doesn't make me lose my hair. My hair is already thin enough as it is. The one side effect that I would not mind having is the loss of appetite but I have not seen that yet!


    Old 07-29-2008, 08:19 AM   #4
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    Re: what are the side effects of taking methotextrate

    GENERIC NAME: methotrexate
    BRAND NAMES: Rheumatrex, Trexall
    DRUG CLASS AND MECHANISM: Methotrexate is classified as an antimetabolite drug which means it is capable of blocking the metabolism of cells. (Metabolism consists of the production and destruction of important components of the cell as well as the production of energy for use by the cell.) As a result of this effect, it has been found helpful in treating certain diseases associated with abnormally rapid cell growth, such as cancer of the breast and psoriasis. Recently, methotrexate has been shown to be effective in inducing miscarriage, for example in patients with ectopic pregnancy. This effect of methotrexate is attributed to its action of killing the rapidly growing cells of the placenta. It has also been found very helpful in treating rheumatoid arthritis, although its mechanism of action in this illness is not known. It seems to work, in part, by altering immunity, which may play a role in causing rheumatoid arthritis.



    PREPARATIONS: Injectable: 25mg/ml; powder for injection 1 g. Tablet: 2.5, 5, 7.5, 10, and 15 mg

    STORAGE: Store at room temperature 15 to 30C (59 to 86F), avoid light.

    PRESCRIBED FOR: Methotrexate is used for cancer treatment generally in higher doses than for other uses and is often administered intravenously or intramuscularly. Methotrexate is used to treat psoriasis, an inflammatory skin disease, as well as the arthritis that occurs in 10 percent of these patients (psoriatic arthritis). It is also used to treat active rheumatoid arthritis in adults and children and other rheumatic diseases, including polymyositis and systemic lupus erythematosus. Methotrexate has been used to induce miscarriage in patients with ectopic pregnancies.

    DOSING: Methotrexate may be taken with or without food.

    For rheumatoid arthritis and psoriasis, the dose of methotrexate is given WEEKLY, by injection or orally.

    For psoriasis, the starting oral dose is a single 7.5 mg dose weekly or 2.5 mg every 12 hours for three doses, once weekly.

    DRUG INTERACTIONS: Using nonsteroidal anti-inflammatory drugs (NSAIDs) before or during methotrexate treatment may result in serious adverse events because NSAIDS may increase the blood concentrations of methotrexate. Combining methotrexate with drugs that adversely affect the liver or kidneys may result in additional liver or kidney toxicity.

    PREGNANCY: Methotrexate should not be used in pregnancy, as it can be toxic to the embryo and can cause fetal defects and spontaneous abortion (miscarriage). It should be discontinued prior to conception if used in either partner. Male patients should stop taking methotrexate at least 3 months prior to a planned conception and females should discontinue use for at least one ovulatory cycle before conception.

    NURSING MOTHERS: Methotrexate is excreted in breast milk and should not be used by nursing mothers.

    SIDE EFFECTS: Methotrexate can be well tolerated, but also can cause severe toxicity which is usually related to the dose taken. The most frequent reactions include mouth sores, stomach upset, and low white blood counts. Methotrexate can cause severe toxicity of the liver, kidneys and bone marrow, which require regular monitoring with blood tests. It can cause headache and drowsiness which may resolve if the dose is lowered. Methotrexate can cause itching, skin rash, dizziness, and hair loss. A dry, non-productive cough can be a result of rare lung toxicity.

    Last Editorial Review: 1/8/2008

    Last edited by MellyMell; 07-29-2008 at 08:20 AM.

    Old 08-04-2008, 01:22 PM   #5
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    Re: what are the side effects of taking methotextrate

    i have been on it now since april and have changed from 8 tablets a week to the injection as i found the side effects bad.headaches and sickness being the worse dose was increased to 20mg injection form an im experiencing the headaches not so much sickness.i also take prednisolone and hydroxychloroquine and also folic acid
    i have read mixed reviews about this medication an it is so worrying.i feel it helps my ra stay at bay but the side effects can be frightening

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