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wifeuvbpd87 11-04-2002 09:45 AM

anyone gained alot of weight from taking advair?
This is my 1st time to this bored..Ive honestly havent been able to find a asthma bored..this is refreshing..
Im 34 years old and homeschool my 3 kids..THAT in itself is a asthma have alot of stress including having a prescription addict fun..So I know that stress is a biggie for me..I have had asthma for 32 years..Ive sucked down albuterol inhalers in a 2 week period for years..Ive just now have been referred to an pulmonologist who has put me on advair..While it was a DREAM for 2 months..I mean i went from using an inhaler every 2 weeks and sleeping with it in my pillow to taking a couple puffs a month..But lately I have gone back to using albuterol alot more especially at night..Im still taking the advair but its lost its flavor..the weight gain is a drag too..
Well i knowIm rambling..but has anyone else ever had this problem and what did u do? Ive tried singulair and alot of the others..So do i need to plan my will?

Brwneyedgirl 11-04-2002 02:09 PM

I don't know what ot say to you. Recently, my pulmonologist put me on Advair. I have been trying to figure out why I was gaining so much weight to the point that my clothes were getting tight. You are correct that it does wonders, but it is glad to know that I am not alone in the weight gain area. Sorry I couldn't be of much help to you, but I wanted to let you know that I understand what you are going through.

lupine 11-04-2002 09:05 PM

The reason you gain weight from advair is because its a steroid, like prednisone, steroids put the weight on, but open those air passages. Lupine

peace1 11-19-2002 12:42 PM

Finally I have some people who agree with me about advair. I gained 10lbs rather quickly and looked on healthboards for someone to agree with me.Did not have much luck. Most people said it was because I did not exercise etc.Not only did I gain weight,I woke up every nite with leg cramps, and was always bloated,fingers, feet etc.I finally got off the drug for the most part. Only use it when I am having alot of trouble. Now I am on singulair, it does not work nearly as good but I cannot just keep gaining weight, I am already obese. Also heard of someones child who was on advair, under age 12 and ended up with nerve damage to the point of living in a wheel chair for months. The side effets are not well known, unfortunately the doctors are also unaware of these side effects on such a new drug. I reccomend getting off advair if you can handle it. Good luck!!

wrin 11-21-2002 09:09 AM

This "new drug" is actually two older drugs that have been extensively tested and used for the last 10 years.

Advair is a combination of two drugs -- Flovent, a corticosteroid brought in to replace the more dangerous Beclovent (beclomethasone), in March 1996.

Serevent, the other component of this "new drug", has been around since February 7th, 1994.

As far as weight gain goes, whenever one is taking any kind of corticosteroid, weight gain is always listed as a side-effect. I hope Singulair is working better for you, and if you're only using Advair when you're having a bad time you should consider switching to straight Serevent as this would eliminate the corticosteroid component altogether.

I am greatly amused by those saying that the side-effects are not well known -- there were several 12-week trials done way before either drug was approved by the FDA, and since then there have been no reports of any kind of neurological damage occurring, at least not reports to reputable sources. If your friend's child was neurologically damaged by advair, I see you live in the states, I'm sure it wouldn't be out of the question for her to sue.

I don't recommend getting off inhaled corticosteroids if you can handle it, simply because the alternatives to them are no prettier, in fact, they are worse.

We'll start with the magic that is Singulair, because it's more well-known. It doesn't work for everyone because it relies on one particular component to counter the inflammation. Corticosteroids are a sort of broad-spectrum anti-inflammatory -- they work by countering the inflammatory process.

The next alternative would be an oral corticosteroid, in a dose something along the line of ... 1,000 times the size of a dose of Flovent, ... and that's the low estimate. Anybody who's ever been on prednisone will tell you that if you can avoid that altogether, you should, simply because the side-effects range from the ugly to the uncomfortable to the horrific. (My grandmother went blind from the neuropathy it can sometimes cause.)

Our next option for a maintenance medication would be a drug that's been mostly dropped by the wayside for the last 20 years -- Theophyllines. They're potent bronchodilators, taken as pills. Their range of effect is also incredibly close to their range of overdose -- and their overdose is a dangerous one. It is for this reason that people taking theophyllines are to go for blood testing every 1 to 3 months to make sure the serum levels in their blood are okay. Many people have died simply from taking doses of theophyllines too close together.

If you have problems in particular with GlaxoWellcome or the combination drug Advair, I would personally point out that Advair isn't really recommended for children under the age of 12, as Serevent doesn't exactly come in tailored dose-sizes. If you are looking for an alternative to Advair, AstraZeneca makes a combination drug called Symbicort, which contains Pulmicort (the only inhaled corticosteroid approved for children under 3) and Oxeze, which is a drug much like Serevent except faster-acting (think 15 minutes) and also coming in a half-dose size.

I've had a lot of luck with it. I suggest you try it.

rugratsmomma 11-23-2002 04:42 PM

Unfortunatly you don't seem to know a lot about drugs in the US..Symbicort isn't available here so its not an option.

As far as Advair,my daughter can't take it.She can take flovent and serevent seperatly but Advair causes horrible side-effects.Which the serevent in Advair is a higher dose than what she took in MDI form.She now takes Qvar(beclomethasone HFA)

wrin 11-23-2002 07:12 PM

[quote]Originally posted by rugratsmomma:
[b]Unfortunatly you don't seem to know a lot about drugs in the US..Symbicort isn't available here so its not an option.

As far as Advair,my daughter can't take it.She can take flovent and serevent seperatly but Advair causes horrible side-effects.Which the serevent in Advair is a higher dose than what she took in MDI form.She now takes Qvar(beclomethasone HFA)[/b][/quote]

Wow that's so weird -- maybe Oxeze hasn't been approved in the USA yet? As far as the research seems to have shown, the doctors like it better than serevent because it acts faster than Serevent, though the powder inhaler isn't for everyone.

I imagine you know that the higher dose of Serevent (though last I checked I thought the doses were the same but perhaps it's different in the states) was probably what was causing her side-effects... sucks that Serevent doesn't come in two different doses. I hope Oxeze is approved down there soon, it comes in a 12ug dose and a 6ug half-dose that seems to cause fewer side-effects in smaller kids, though it's still not recommended for those under 12, much like Serevent.

Has the HFA been working better for her than the CFC MDIs? Too bad fluticasone doens't come in HFA quite yet, because Flovent has been shown to have fewer side effects than beclomethasone, and if she can tolerate that in MDI, my personal bias says that it might be a better option.

Pulmicort still comes in nebulized format in the USA.

golflady 11-29-2002 09:40 AM

Hi everybody! I am new to this board. I have been on Advair for about 2 years. It worked great in the beginning. I am 54 but have never had a weight problem. Just lucky. I have gained about 8 pounds since I started Advair. Then about a month ago I noticed alot of voice problems. I have been very hoarse for about 3 weeks. I decided to go off the Advair 2 weeks ago. Developed a bad case of congestion. I went back on accolate. I hope this works, my doctor also put me on 1000 mg. of biaxin. I hope this works and my voice goes back to normal. Has anyone else had voice problems from Advair? Glad I found this board.

wrin 11-30-2002 11:06 AM

Not advair specifically, but I had voice problems with Flovent. I sing, so I noticed them right away, and it took me about three seconds to get REALLY annoyed with them.

So I switched to pulmicort, and life is good :) I'm now taking Symbicort, it's a combo kind of like advair except instead of Serevent it's got Oxeze in it (I think in the States this is marketed as Foradil) and it works like a *charm*.

I hope the accolate is working well for you, I've never tried a leukotriene receptor antagonist, I hear they're kind of a hit-and-miss thing, either they work REALLY well or they don't work hardly at all. I hope you're in the former -- I understand the list of side-effects is rather short.

There are other inhaled corticosteroids on the market, that are available in different formats. The powder is hard to take if you have severe asthma because you have to generate a very high peak inspiratory flow to get the powder to not deposit in your mouth. Many have found taking Flovent MDI and Serevent MDI with an aerochamber or spacer instead of just taking advair was mildly more inconvenient but worked a bunch better.

Subshine 12-17-2002 03:38 AM

Unfortunately, there is no such thing as drugs without side-effects. We live in, and have been conditioned by, a society that is so drug-oriented that we have to take one drug to counteract another. Also, unfortunately, doctors are not trained to treat the body in a wholistic way and have no knowledge about natural healing methods that have been used for ages, before we became a drug culture.

There is a gentle, good-tasting herbal product called RespirActin that opens the airways almost immediately. Taken on a continued basis, it also works to prevent asthma attacks. It is safe for children and adults, has no ephedra or caffeine, and can improve the quality of your life immeasurably. It does all that the inhaled steroids try to do, without any of the dreaded side-effects. It needs no presciption. It has saved my life, along with quercetin and bromelain. Drugs of all kinds make me severely ill and exacerbated the asthma.

Did you know that a recent survey reveals that 75% of asthma sufferers are non-compliant about prescribed drugs, no matter how severe the asthma, because of the horrible side-effects that can be felt immediately or, most often, in time? Becoming informed about how to boost the immune system is the best way to deal with asthma, and this product will help do just that.


wrin 12-17-2002 09:14 AM

Let me just sneak in quietly to say that if you are planning to take holistic or herbal remedies to inform your doctor and pharmacist and holistic practitioner (as you should not just haphazardly start taking herbs -- they are drugs too, and can have side effects too, and should be overseen by someone who knows what the heck they're doing) so they can make sure that your herbs and prescriptions don't interact in a muchly bad way. Lots of drug interaction problems have happened becuase people began taking herbs without informing their doctor while they were on other prescription medications, most notably hypertension medications.

Despite what some may think, most doctors are genuinely interested in seeing their patients get better -- and if your improvement with herbs is what it takes, it might take just that little bit of convincing to get your doctor to suggest the option to his other patients, and I'm sure your holistic practitioner wouldn't mind a little word-of-mouth free press about how awesome his practise is.

Gailfer 02-10-2003 09:28 AM

I hear you! I've been taking 250/50 Advair since Nov., when I developed asthma out of the blue. It's totally allergy related because when my husband and I moved in together we had 3 cats between us! I had originally attributed my weight gain since that time to my honeymoon and then going into the holidays. Then my husband and I went on Atkins and I've barely lost anything and I'm about 7 lbs. heavier than I should be. I even just got my thyroid tested. My husband, who works in the pharma industry, told me that it's probably the Advair and then we found this site and other related sites. I'm going to ask my allergist to put me on Singulair. I didn't realize that Advair was a true steroid that would give you the bad side effects and it makes me mad since I had to go on Prednisone briefly 2 yrs. ago and it made me feel awful. Anyhow, I'm really big around the middle, inc. my hips and my face looks fat. Has anyone gone off of Advair after gaining weight and the weight came off? If so, did it come off quickly?

charleyhorse 02-10-2003 06:54 PM

Hi everyone. Just wanted to echo was Wrin said about reading labels and knowing your meds(herbal, prescription or otherwise). I see a naturpath, a family dr and two respiraologist. Everyone knows what everyone else is doing. All reports, tests etc go to the whole gang. There are plenty of family doctors out there who are quite open to the involvement of naturpaths and other alternative treatments. Please remember that just because something is herbal or 'natural' doesn't mean it is automatically safe. Respiractin, for example contains the following ingredients ... Rosemary, Honey, Witch Hazel,Fenugreek Seed, Black Seed, King Solomon Seed, Ginseng Powder, Damiana Leaves, Marshmallow, Sage, Juniper Berries, Chamomile Flowers, Cloves, Cinnamon, Spearmint and Thyme. I am highly alergic to cinnamon (this is quite common in people with tree pollen allergies.) Fortunately, my naturpath warned me about this product before I wandered into a health food store and tried it without reading the label. I believe in trying anything that's reasonable and, if it works for you, wonderful! But please read the labels, do the research and keep your whole health care team in the loop.


wrin 02-10-2003 07:29 PM

Thanks charleyhorse -- I can come up with at least three examples off the top of my head where someone was taking a prescription drug and just started on a herbal for the hell of it -- one of which I can remember is the bad bad bad interaction that St John's Wort has with any drugs used for clotting -- like, the part where it can cause severe bleeding.

And high-blood-pressure meds are famous for this too.

Go to a holistic practicioner, go to a naturopath, go to a herbalist, go to someone with more training than YOU have. Go to a herbal specialist, and don't just talk to Jimmy behind the counter at GNC. He might not know what he's talking about based on your medical history and particular allergies.

Thanks again, Barb, if we can keep people from ending up sicker from herbals, we'll be able to give them a better name.

laci 02-11-2003 11:58 AM

This will really get everyone depressed! But here goes--
Singular put weight on me too, as Advair has done, and prednisone.
In fact, I notice a little weight even from Rhinocort. I hear some people can be very sensitive to steroids and have that side effect.

charleyhorse 02-15-2003 11:28 AM

Here's some more bad news about weight gain :( All the steroids tend to have this effect because they stimulate your appetite. This is wonderful if you suffer from being underweight (yeah, right). However, most of us will gain weight on steroids because our brain tells us we are starving and ... guess what ... we eat. They also tend to make you retain water, just as an added bonus.


wrin 02-16-2003 02:10 AM

Umm. That's part of it

Steroids also make for more free available glucose in your blood, or just a naturally higher blood sugar -- which in most people isn't a problem but it can be in diabetics, and can also contribute to a weight gain problem since you tend to not 'throw away' as many carbs.

Bienkie 02-17-2003 08:05 AM

I statred taking Advair in July 2002 and started gaining weight. I had no idea what caused it. Went to the best Nutritionist - NOTHING worked. Worked out every day. I gained 15 lbs. I used to be very skinny. It seems to me it could be the Advair, listing to some of your stories. Does the weight come off when you stop the Advair? I'm going to call my doctor today for an appointment. Good luck to all!

lacii 02-17-2003 01:17 PM

Yes, the weight comes off when you go off Advair. I also plan on getting off after I get this inflammation under control.
I also have lost my voice after my 2nd inhalation of Advair daily. I'm taking one dose now.

Gailfer 02-20-2003 01:10 PM

Thanks for all of your input. As a follow up to my previous posting, I've been off Advair a few weeks now and have been taking Singulair. My dr. thought I was nuts and told me I couldn't have gained weight from Advair (whatever, I'll be the true judge). My weight hasn't budged yet but there may be other factors. BUT sad to say, Singulair isn't totally cutting it by itself. It's better than nothing but I am more winded. I figure maybe I can just take Advair a few times a week? Who knows - it's all such a crapshoot!

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