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    Old 08-09-2015, 09:20 PM   #1
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    I have had three positive ANA tests this year and nothing showing up with the rheumatologist. Now, I've been tested again for B12 and this is what my results read... Can anyone help decipher this for me? Thank you.

    Iron: 74ug/DL (lower end)
    TIBC: 458 (high)
    % Saturation: 16% (lower end)

    Folate Serum: >24 (high)

    B12: 285pg/mL (low)
    Alkaline Phosphatase: 33 (low)

    I started this process 2 years ago. I am 26, decently active, and I have hand stiffness/pain that is sometimes disabling. I cannot grip a steering wheel in the morning. I also suffer from severe fatigue. I have "minor" carpal tunnel in one hand and a 12.5mm pineal cyst, currently. Doctors say the pineal cyst doesn't cause any of these symptoms. Any thoughts?

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    Old 08-12-2015, 10:32 AM   #2
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    Re: Bloodwork

    Hi. I'm sorry you're struggling. ANA is a very "general" test, unfortunately; so in & of itself, it can't diagnose anything. That said, do you know how high your ANA results have been? (The higher ANA is, the more likely a true AI condition. But *lower* positives are possible due to a passing viral or bacterial infection, due to a family tendency, etc.)

    Also, I'd want to know exactly which *more specific* tests the rheum has run. Those would give strong hints as to which conditions he's considered. You could get copies, then post all test names, adding the actual values & reference ranges for any that have been abnormal.

    Some AI's can take awhile to build, so it can awhile for labs to catch up with symptoms, even when the "right" labs are being diligently run. And in some AI's, like RA for one, many people may not "present" with positive labs; and even worse, some people with RA NEVER turn seropositive for certain key tests. And these are only several examples of why the AI's can be extremely challenging.

    Re your low-ish iron, I think many women can have low iron simply due to heavy or prolonged periods. And do you have any GI issues? (GI conditions like Celiac can deplete iron, I think.)

    Re hand pain, is in both hands or just one?

    Re B12, I don't know in what conditions it typically depresses (sorry), so I hope others weigh in.

    Were your thyroid values checked?

    Sorry the above is sort of rambling. (I actually started with some relatively clear thoughts. ) Looking forward to hearing more & sending warm wishes. Bye for now.

    Old 08-12-2015, 02:53 PM   #3
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    Re: Bloodwork

    The 3 positive ANA's, iron deficiency, B12 deficiency can all be present in autoimmune disorders. It would be helpful to know how high (titer) the ANA's are, and what your ferritin level (stored iron) and hemoglobin/hematocrit are. B12 deficiency can occur in pernicious anemia, an autoimmune disorder. The fatigue you have may respond somewhat to iron and B12 supplementation, but it seems you need to have more tests run to really get a handle on what this is. Like Vee suggested, if you have any other test results you can post, it would be helpful, even negative ones that were run or normal values. A urine test is very helpful to look for signs of lupus affecting the kidneys. Since your hands hurt, xrays may be helpful to look for signs of arthritis, and a sed rate and CRP on blood to look for inflammation. I would not worry about the high folate or low alk phos, as that should pose no problem to your health.

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