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    Old 10-08-2007, 07:09 AM   #1
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    Carcinoma In-Situ Question

    I have been reading a lot of posts on this board where people are saying that carcinoma in-situ is cancer. I have been diagnosed with adenocarcinoma in-situ and my doctor assures me that this is still a pre-cancerous condition, essentially Stage 0. I was under the impression that the term "-in-situ", whether carcinoma-in-situ or adenocarcinoma-in-situ, refers to a premalignant lesion, not an invasive cancer. Is this incorrect?

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    Old 10-08-2007, 08:01 AM   #2
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    Re: Carcinoma In-Situ Question

    It is my understanding that it means cancer in place, or cancer which has not spread elsewhere. I recently underwent a TAH for the same issue and my biopsy results following my surgery showed that the cancer had not invaded any further than my cervix. I wonder if this is comparable to skin cancer that has not spread. Remove the spot and surrounding tissue and we are ok??? Just a thought........

    Old 10-08-2007, 08:44 AM   #3
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    Re: Carcinoma In-Situ Question

    This is a very confusing subject. I was told when diagnosed that adenocarcinoma in situ (AIS) is NOT cancer. Yes, "in situ" means it is localized. However it is my understanding that AIS is not cancer but a more aggressive and more difficult to detect precancer. It is higher in the canal which is why it is more difficult to detect. AIS is very treatable. Hope this helps!

    Old 10-08-2007, 09:42 AM   #4
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    Re: Carcinoma In-Situ Question

    I have discussed this with my consultant and basically, without lots of medical terminology, he informed me that it was most definately pre-cancer and was the last step before turning into a 'true' cancer...

    Old 10-08-2007, 12:22 PM   #5
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    Re: Carcinoma In-Situ Question

    It depends on who you talk to, I think.

    In my research, I found that carcinoma in situ (CIS) is often referred to as Stage 0 cervical cancer. The cells that make up the thickness of the tissue are all abnormal, but the abnormal cells haven't spread through the "basement membrane" that contains them. So, the cells are cancerous, but the cancer hasn't spread beyond where it started.

    Other articles I have read state group CIS with HGSIL (CIN 3 or severe dysplasia) and state that it's pre-cancer.

    When I got the call from my gyn telling me that my biopsy showed carcinoma in situ, the nurse told me that my doctor wanted me to see a gyn/oncologist, but that he said I shouldn't worry because CIS wasn't cancer or even pre-cancer. I'm not sure why the heck he said that, because CIS is very clearly pre-cancer and maybe even cancer. But then, he was always a bit overly optomistic anyway.

    Old 10-13-2007, 08:54 AM   #6
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    Re: Carcinoma In-Situ Question

    I have an overly optomistic Gyno/oncologist that is telling me that CIS is just dysplasia.

    My Gyno(who the oncologist calls a drama queen) is assuring me that CIS is most definatly Cancer and should be veiwed as just that Cancer and not Dysplasia.

    Shashi is right, I totally depends on who you talk to!

    Last edited by purplepiegirl; 10-13-2007 at 08:55 AM.

    Old 10-21-2007, 07:48 AM   #7
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    Re: Carcinoma In-Situ Question

    HI, I was told that it's a very localized area of cancerous cells confined to the surface cells only that have not yet spread, but the likelihood of it spreading without any treatment is very high. I have alot read that it is called Stage 0.

    I had the same thing, adenocarcinoma-in-situ, and with glandular involvement. I had a cold knife cone done late last November and it was found after that biopsy. And I had a large section removed, but the margins came back clear. Well, for 2 follow up paps after over 6 months, those also came back perfectly clear. Now all of a sudden my last pap in August came back as HGSIL again! My doc was even talking to another doc in the group and they were talking possible hysterectomy for me. Now I have an appt this Wed for another colposcopy, ughhh. I just have a feeling that I'm not going to get any good news. My gyno did say she would give me some referrals for gyno-oncologists if it looks like I might need hysterectomy.

    Old 10-23-2007, 07:34 AM   #8
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    Re: Carcinoma In-Situ Question

    Staging varies greatly from Cervical Cancer to Abnormal Cervical Cells - See below:

    Here's the difference:
    Cervical Cancer
    Stages 0 - 4
    0 - Carcinoma In Situ
    1 - Cancer in neck of the womb
    2 - Cancer spread around neck of womb
    3 - Cancer spread to pelvis
    4 - Cancer spread into other organs.

    Abnormal Papsmear - Dysplasia staging
    CIN I - Mild dysplasia and HPV detected
    CIN II - Moderate dysp. with abnormal cells taking up 1/2 the thickness of the cervix lining.
    CIN III also referred to as carninoma in situ is severe dysplasia and the entire cervix lining is comprised of abnormal cells BUT the cells have not spread beneath the lining.

    FYI I was diagnosed with an abnormal pap back in 1998. I was told it was a CIN III. And had a LEEP done .... Thankfully all paps have been normal since. Almost 10 years and 2 kids later. LEEPs have a higher success rate than cryo's I understand.

    Old 10-31-2007, 10:41 PM   #9
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    Re: Carcinoma In-Situ Question

    Hi I am not sure but some of the post are so old and things in the medical world have changed so much. I have been going through the roller coater for about a month now not because of any one specific health care person but more because things just wouldn't line up like appointment and starting my period and stuff like that. Anyway just to hopefully make people think or at least get a second opinion or make the correct decision for them here is my story. I had an abnormal pap come back HGSIL Favor Neoplasia and was sent to a specialist and the same things happened I started and things got screwed up however I got to go in and have a colposcopy and the doctors all said oh HGSIL and favor Neoplasia are not cancer and bla bla bla well guess what? I got a call yesterday and was called in today to have an endomitrial biopsy and was told that I have cervical cancer and the bad one "adenocarcinoma" there are only two worse stages then what I have yet they try and tell people this is not cancer??? My doctor told me straight when I asked him. THAT I HAVE CERVICAL CANCER no sugar coating he said I will be contacted tomorrow by an oncologist/surgeon and my options will be disgust but he can assure me most likely it will be a cold cone biopsy and the next day a hysterectomy. You know I just want straight answers and the bottom line and I think everyone coming to these types of sights wants the same and sometimes people know others too well and get to personally involved so it is hard to tell the hard facts. I have read so many post from here and other's who had similar diagnosis as me and they got such broad speculated recommendations and then down the months and years had to under go what I have been told I will right off the bat and I just want to make sure that everyone is informed because this sucks so very much but knowledge is power and you life is worth saving. Good luck al I will keep you posted and I am sorry if this was harsh but I feel so strong about just being truthful and cervical cancer is cancer no matter what degree!!!!!

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