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  • CEA Rise after 1st chemo

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    Old 11-04-2006, 06:14 PM   #1
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    CEA Rise after 1st chemo

    Hello all,
    Has anyone had the experience of your CEA rising
    after the 1st treatment of chemo? My onc at Stanford
    said before I started that it could rise on the
    first treatment.

    The details are as follows. I was dx Stage 4, 1
    liver met on 8/28. I had successful colon surgery
    and started chemo on 10/10. I did have a CT scan
    done on 10 /9 that still showed only the one liver
    met. It had increased in size from the 8 /29 CT scan
    from 2.1 to 2.8 cm.

    I am on Erbitux, Xeloda , and Oxylaplatin with a
    scheduled 3 cycles before liver surgery. That is
    also why they did not add Avastin because of the
    early surgery. I have met with the surgeon and tumor
    board at Stanford as well. They suggested do the
    chemo first to evaluate the effectiveness and
    protocol for post surgery chemo. They also mentioned
    the effects of post surgery growth hormones released
    by the body following the colon surgery and if the
    liver surgery was done in Oct they felt it would be
    in my best interest in terms of preventing
    reoccurance to have pre surgery chemo.

    My post surgery CEA was 10.6 on 10/2. The last blood
    draw had me at 17.1 after the first cycle on 10/26.
    Obviously you want to see a downward trend over the
    3 cycles but I was not encouraged. Any thoughts?
    Thank You

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    Old 11-05-2006, 05:48 AM   #2
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    Re: CEA Rise after 1st chemo

    The way it was explained to me is that the first treatment attacks the cancer cells and they explode in response to the chemo, creating the rise in numbers. I always visualized it like the Raid commercial! However, if it does not come down, then I would have a new scan and deal with a change in chemo.


    Old 11-06-2006, 06:41 AM   #3
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    Re: CEA Rise after 1st chemo

    ImpactZone, I have read past posts here where lots of folks had their CEA rise in response to chemo -- if your drs are not concerned, I wouldn't be. I know, I know, easier said than done. But unless my memory is failing faster than I believe is possible, several folks here had their CEA go up during chemo and in the immediate aftermath.

    Hopefully folks will respond and share their experiences ---


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