It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Cancer: Prostate Message Board

  • PSA down after SBRT bone lesion Dec.2019

  • Post New Thread   Reply Reply
    Thread Tools Search this Thread
    Old 02-04-2020, 11:00 AM   #1
    Steve135
    Senior Member
    (male)
     
    Join Date: Dec 2019
    Location: NJ
    Posts: 134
    Steve135 HB UserSteve135 HB UserSteve135 HB User
    PSA down after SBRT bone lesion Dec.2019

    My PSA is on its way down after receiving 3 SBRT treatments in Dec. 2019! After the second BCR 5/2019 with no conclusive Pet image a second Pet in 11/2019 shown an uptake in my left iliac bone! Trelstar,Xtandi, Zoldronic transfusions brought the psa back down from 0.34 to 0.07 which was up from 0.006 after first BCR. 16 days after SBRT psa 0.06 and now a month later 0.04 Tells me they at the very least hit the spot? Hoping they zapped all of it and I have the fortune not to have anymore bone lesions! My Uro was confused as there had been other small images on previous Pets that no longer can be seen? These were on my right femur and pelvic region? Its always a plus to see the psa going down for the mindset.
    steve d

    _________________
    Diag. 56 DOB 2/59 PSA 01/14 2.0 6/15 2.4
    Biopsy 6/15 5 Gleason Score 8
    RP 10/15 Path 54g 5x4.2x2.8cm 4+3=7 Tumor location quadrants Bilateral
    Extra-capsular extensions present,SV no invasion
    Vascular invasion none, PNI ,Multicentricity multifocal
    Margins NP lN's 5 neg pT3a,N0
    PSA 10/16 0.1 1yr 02/7/17 0.4 02/15/17 0.5
    Pet Scan 2/17 Neg PSA 03/17 0.6 Axumin trial 17.4mm BCR rt. SVB Casodex + Trelstar
    04/17 SRT (42)
    08/17 PSA 0.1 Last 6 uPSA 0.006 uPSA 2/19 0.030 2nd BCR 5/19 0.235 5/30 0.32 6/19 0.34 7/19 0.06 8/19 0.08 9/19 0.056
    10/190 0.08 11/19 0.07 12/19 0.07 1/ 27 0.06
    7/19 Trelstar, Xtandi, Zoledronic Acid
    12/19 (3) SBRT Iliac bone liasion

     
    Reply With Quote
    The following user gives a hug of support to Steve135:
    IADT3since2000 (02-05-2020)
    Sponsors Lightbulb
       
    Old 02-04-2020, 11:22 AM   #2
    DjinTonic
    Veteran
    (male)
     
    Join Date: Dec 2019
    Location: NC
    Posts: 454
    DjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB UserDjinTonic HB User
    Re: PSA down after SBRT bone lesion Dec.2019

    That's great PSA news, Steve. Let's have more good news going foward, too!

    Djin
    __________________
    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3-
    7-05-13 TURP for BPH (90→30 g) path neg. for PCa, then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Nodule negative for PCa. Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
    SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
    pT2c pN0 pMX, G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    Dry; ED OK with sildenafil
    Decipher 0.37 (Low Risk), uPSA: 0.010 (3 mo.)...0.020 (3 yr. 7 mo.)

     
    Reply With Quote
    Old 02-04-2020, 11:35 AM   #3
    Michael F
    Member
    (male)
     
    Join Date: Dec 2019
    Location: Greater Atlanta
    Posts: 80
    Michael F HB UserMichael F HB UserMichael F HB UserMichael F HB User
    Re: PSA down after SBRT bone lesion Dec.2019

    Hi Steve135! Congrats on the retreating PSA!!!

    As the old saying goes: "A decreasing PSA is Good!"

    So glad that 2020 is off to a great start!

    MF
    __________________
    PSA: Oct '09 = 1.91, Oct '11 = 2.79, Dec '11 = 2.98 (PSA, Free =13%)
    Jan '12: Biopsy: 1/12 = G7 (3+4) & 5/12 = G6
    March '12: Robotic RP: Left: PM + EPE => Surgeon went back and excised additional adjacent tissues on Left side down to (-) Margins
    Pathology: Gleason (3+4) pT3a pNO pMX pRO c tertiary pattern 5 / Prostate Size = 32 grams / Tumor = Bilateral: 20% / PNI: present
    uPSA Range: 0.017 - 0.039 at 105 Months Post Op: Mean = 0.023 (n = 26)
    LabCorp: Ultrasensitive PSA: Roche ECLIA
    Continence = Very Good (≥ 99%) ED = present

     
    Reply With Quote
    Old 02-05-2020, 09:15 AM   #4
    IADT3since2000
    Senior Veteran
    (male)
     
    Join Date: Nov 2007
    Location: Annandale, VA, USA
    Posts: 2,867
    IADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB User
    Re: PSA down after SBRT bone lesion Dec.2019

    Hi Steve. Congratulations on your great results!

    I had a friend who successful worked through at least three recurrences where images detected one or two spots each time, finally achieving long-term success.

    Dr. Eugene Kwon, a renowned recurrence fighter at the Mayo Clinic, Rochester, Minnesota, has used treating dandelions in the lawn as an analogy for getting rid of a few pesky mets that pop up. Sometimes you get all plants that have sprouted from seeds with a one-time shot, but sometimes you have to go back a few times with radiation or surgery to get the ones that were too small for detection at the times of the first or second (or more) attempts. I know of one of his patients who said he had gone through this many times, but at the time he spoke two or three years ago, his PSA was undetectable. Also, in contrast to having just a few mets where such therapy can be successful, this patient had numerous mets, a situation where spot therapy is often not successful. His extraordinary success shows what can sometimes be achieved.

    Quote:
    Originally Posted by Steve135 View Post
    ... My Uro was confused as there had been other small images on previous Pets that no longer can be seen? These were on my right femur and pelvic region? ...
    It might be to a suspected favorable impact of radiation on metastases that are beyond the range of the radiation field. One theory for this so called "abscopal effect" is that the radiation that is on target causes the cells being destroyed to release identifiers that teach our immune systems to recognize them as foreign, which then helps the immune system to go after and destroy distant cancer cells.

    Jim

    - - - - - - - - - - - - - - - - - - - - - - - -
    Diagnosis Dec 1999 PSA 113.6 (first ever), age 56
    Gleason 4+3=7 (J. Epstein, JHU), all cores +, most 100%; "rock hard" prostate with ECE - stage 3, PNI, PSADT determined later 3-4 months; technetium bone scan and CT scan negative; prognosis 5 years.
    Later ProstaScint scan negative except for one suspicious small area in an unlikely location. ADT Lupron as first therapy, in Dec 1999, then + Casodex in March 2000, then + Proscar and Fosamax in Sep 2000. Rejected for surgery January 2000; offered radiation but told success odds were low; switched to ADT only vice radiation in May 2000, betting on holding the fort for improved technology; PSA gradual decline to <0.01 May 2002. Commenced intermittent ADT3 (IADT3) with first vacation from Lupron & Casodex. Negative advanced scans in 2011 (NaF18 PET/CT for bone) and 2012 (Feraheme USPIO for nodes and soft tissue). With improved technology, tried TomoTherapy RT, 39 sessions, in early 2013, plus ADT 3 in support for 18 months (fourth round of IADT3), ended April 2014. Continuing with Avodart as anti-recurrence shield. Current PSA remarkably low at <0.01; apparently cured.. Supportive diet/nutrition, exercise, supportive medications during this journey, as well as switches in antiandrogen, 5-ARI, and bone drugs.



     
    Reply With Quote
    The Following User Says Thank You to IADT3since2000 For This Useful Post:
    Steve135 (02-07-2020)
    Reply Reply




    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off




    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 09:31 PM.





    © 2021 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!