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  • Testicular Pain

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    Old 06-09-2021, 06:45 PM   #1
    JWPMP
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    Testicular Pain

    Has anyone experienced testicular pain while on Lupron and Abiraterone?

     
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    Old 06-10-2021, 12:02 PM   #2
    IADT3since2000
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    Re: Testicular Pain

    Hi Paula,

    I haven't heard of that side effect, so I did a search of www.pubmed.gov for - Lupron AND testicular pain - which yielded no relevant information in three listed studies - basically false hits. I did the same for - Zytiga AND testicular pain - and got no results at all.

    However, in the FDA's guide to the drug, at https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019010s038lbl.pdf#page=27 , there is a mention on page 7 of testicular pain as a reported side effect in less 5% of patients. It's possible that is coincidence, but it could be a rare but real side effect.

    I hope you get a response from someone with first hand knowledge of this issue.

    .Jim

    - - - - - - - - - - - - - - - - - - - - - - - -
    21 years as a survivor. Doing well. Diagnosis Dec 1999 PSA 113.6 (first ever), age 56
    Gleason 4+3=7 (J. Epstein, JHU), all cores +, most 100%; "rock hard" prostate with ECE - stage 3, PNI, PSADT determined later 3-4 months; technetium bone scan and CT scan negative; prognosis 5 years.
    Later ProstaScint scan negative except for one suspicious small area in an unlikely location. ADT Lupron as first therapy, in Dec 1999, then + Casodex in March 2000, then + Proscar and Fosamax in Sep 2000. Rejected for surgery January 2000; offered radiation but told success odds were low; switched to ADT only vice radiation in May 2000, betting on holding the fort for improved technology; PSA gradual decline to <0.01 May 2002. Commenced intermittent ADT3 (IADT3) with first vacation from Lupron & Casodex. Negative advanced scans in 2011 (NaF18 PET/CT for bone) and 2012 (Feraheme USPIO for nodes and soft tissue). With improved technology, tried TomoTherapy RT, 39 sessions, in early 2013, plus ADT 3 in support for 18 months (fourth round of IADT3), ended April 2014. Continuing with Avodart as anti-recurrence shield. Current PSA remarkably low and stable at <0.01; apparently cured (Current PSA as of 12/2/2020). (Current T 93 12/2/2020.) Supportive diet/nutrition, exercise, supportive medications during this journey, as well as switches in antiandrogen, 5-ARI, and bone drugs. Barely noticeable side effects from radiation; continuing low T, likely do to long use of ADT, but good energy and adequate strength. I have a lot of School of Hard Knocks knowledge, and have followed research, which has made me an empowered and savvy patient, but I have had no enrolled medical education. What I experienced is not a guarantee for all but shows what is possible.

     
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    Old 06-10-2021, 06:25 PM   #3
    JWPMP
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    Join Date: Jul 2020
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    Re: Testicular Pain

    Quote:
    Originally Posted by IADT3since2000 View Post
    Hi Paula,

    I haven't heard of that side effect, so I did a search of www.pubmed.gov for - Lupron AND testicular pain - which yielded no relevant information in three listed studies - basically false hits. I did the same for - Zytiga AND testicular pain - and got no results at all.

    However, in the FDA's guide to the drug, at https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019010s038lbl.pdf#page=27 , there is a mention on page 7 of testicular pain as a reported side effect in less 5% of patients. It's possible that is coincidence, but it could be a rare but real side effect.

    I hope you get a response from someone with first hand knowledge of this issue.

    .Jim

    - - - - - - - - - - - - - - - - - - - - - - - -
    21 years as a survivor. Doing well. Diagnosis Dec 1999 PSA 113.6 (first ever), age 56
    Gleason 4+3=7 (J. Epstein, JHU), all cores +, most 100%; "rock hard" prostate with ECE - stage 3, PNI, PSADT determined later 3-4 months; technetium bone scan and CT scan negative; prognosis 5 years.
    Later ProstaScint scan negative except for one suspicious small area in an unlikely location. ADT Lupron as first therapy, in Dec 1999, then + Casodex in March 2000, then + Proscar and Fosamax in Sep 2000. Rejected for surgery January 2000; offered radiation but told success odds were low; switched to ADT only vice radiation in May 2000, betting on holding the fort for improved technology; PSA gradual decline to <0.01 May 2002. Commenced intermittent ADT3 (IADT3) with first vacation from Lupron & Casodex. Negative advanced scans in 2011 (NaF18 PET/CT for bone) and 2012 (Feraheme USPIO for nodes and soft tissue). With improved technology, tried TomoTherapy RT, 39 sessions, in early 2013, plus ADT 3 in support for 18 months (fourth round of IADT3), ended April 2014. Continuing with Avodart as anti-recurrence shield. Current PSA remarkably low and stable at <0.01; apparently cured (Current PSA as of 12/2/2020). (Current T 93 12/2/2020.) Supportive diet/nutrition, exercise, supportive medications during this journey, as well as switches in antiandrogen, 5-ARI, and bone drugs. Barely noticeable side effects from radiation; continuing low T, likely do to long use of ADT, but good energy and adequate strength. I have a lot of School of Hard Knocks knowledge, and have followed research, which has made me an empowered and savvy patient, but I have had no enrolled medical education. What I experienced is not a guarantee for all but shows what is possible.
    Wow Jim, thanks for the in depth search! I Googled but found zero.
    I wanted to message Dr Borno but Jim said no. He says today it is much better. So maybe something else entirely. Due to his testicular cancer in 1992, he only has one testicle.
    Thank you again.
    Paula

     
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