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  • Is PC back: 15 yrs

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    Old 06-16-2021, 04:25 AM   #1
    cricket2591
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    Is PC back: 15 yrs

    Had PC Gleason8. Had the surgery; recurence immediate thereafter. Lupron and radiation and 10 yrs cancer free w/o further treatment. Oncology turned me lose and after 5 yrs I requested PSA. Came back at 0.09. During Oncology visits years ago I did have a .1 but oncology said could be just error in the test....Next 4 yrs "undetectable". Any thoughts? Scheduled PSA in 3 months. Oncology did say years ago they don't get concerned until consistant .12-.13. I guess just wait and see but if it is back what are my options. My PSA double time 15 yrs ago was 10 months and doing simple math maybe I'll be OK for awhile if things are the same. I'm 70. Test at same hospital lab as previous.

    Thanks
    Dave

     
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    Old 06-16-2021, 09:46 PM   #2
    Insanus
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    Re: Is PC back: 15 yrs

    The normal definition of BCR is 0.20 on two consecutive tests, but most studies that extend past 10 years use 0.40 on two tests for BCR.

     
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    Old 06-17-2021, 03:52 AM   #3
    DjinTonic
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    Re: Is PC back: 15 yrs

    Quote:
    Originally Posted by Insanus View Post
    The normal definition of BCR is 0.20 on two consecutive tests, but most studies that extend past 10 years use 0.40 on two tests for BCR.

    In fact, Johns Hopkins originally proposed 0.4 as a BCR definition; however 0.2 is now the usual definition in studies. The reasoning was that some men plateau following an initial PSA rise after surgery.

    Djin
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    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3-
    7-05-13 TURP for BPH (90→30 g) path neg. for PCa, then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Nodule negative for PCa. Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
    SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
    pT2c pN0 pMX, G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    Dry; ED OK with sildenafil
    Decipher 0.37 (Low Risk), uPSA: 0.010 (3 mo.)...0.020 (3 yr. 7 mo.)

     
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    Old 06-17-2021, 09:36 AM   #4
    Gary I
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    Re: Is PC back: 15 yrs

    Given your age, surgery, radiation and hormones followed by a decade of 'no worries', I suspect you have little to worry about now.

    Hopefully you're being seen at a center of excellence, by a PCa experienced RO or MO.

    The definition of when BCR actually occurs, is a slippery slope, and with your variables it could be as high as 0.50, or more. Al least that's what my Uro and RO tell me.

    Good luck to you!
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