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  • Capsules vs. Tablets ?

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    Old 01-14-2022, 06:30 AM   #1
    Steve135
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    Capsules vs. Tablets ?

    I have not come up with not a clear answer.
    I have been taking Xtandi (Enzalutamide) Capsules for 2 1/5 years.
    Due to insurance my specialty pharmacy changed. I spend 2 hours on the phone with the new pharmacy because the Xtandi didn't follow me from old to new. I was finally able to get the prescription verbally moved.
    The question is I received Tablets instead of Capsules.
    Everything is same same as far as dose. Tablets are easier to store that Capsules (temperature wise).
    I have already accepted and opened the packaging they are mine to keep. I will start taken them in 5 days.
    I wondering if there is/was a reason why I was taken Capsules Vs. Tablets?
    I see the Oncologist in 13 days, he will be able to fix this if he requires Capsules for next month!

     
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    Old 01-14-2022, 08:51 AM   #2
    DjinTonic
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    Re: Capsules vs. Tablets ?

    Enzalutamide comes as a table and a capsule. Perhaps you were taking a brand of enzalutamide other than Xtandi.

    This Xtandi webpage says they are 40 or 80 mg tablets (top left):


    https://www.xtandi.com/how-to-take?gclid=CjwKCAiA24SPBhB0EiwAjBgkhpY1m HGoaxwjiZVev5p19Dbvt0c7FlPcWaPr2SKvJgEBj qHpKgKorhoCCoIQAvD_BwE&gclsrc=aw.ds

    See also picture of the tablets at Xtandi's physicians' info page here:

    https://www.xtandihcp.com/dosing/dosing-administration?utm_source=google&utm_med ium=cpc&utm_term=xtandi%20tablets&utm_ca mpaign=gs-branded%20treatment&utm_content=gs-branded%2040%20mg%20tablets_ph&gclid=Cjw KCAiA24SPBhB0EiwAjBgkhnLFv000XlqQPi45kzK Iw-Rsx42jmy1l1UR1miF1US23Zu9tPFucmxoCY0UQAv D_BwE

    "XTANDI is offered in a tablet formulation" (No mention of Xtandi in capsules.)
    __________________
    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3-
    7-05-13 TURP for BPH (90→30 g) path neg. for PCa, then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Nodule negative for PCa. Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
    SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
    pT2c pN0 pMX, G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    Dry; ED OK with sildenafil
    Decipher 0.37 (Low Risk), uPSA: 0.010 (3 mo.)...0.020 (3 yr. 7 mo.)

     
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    Old 01-14-2022, 09:54 AM   #3
    IADT3since2000
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    Re: Capsules vs. Tablets ?

    I'm puzzled why the drug comes in both forms, which seem so similar.

    Just to add to the story, here's the US FDA site about enzalutamide capsules: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203415s014lbl.pdf

    While India denied the patent and has a generic version, it looks to me like the FDA site is describing a brand name Xtandi capsule.

    Jim

     
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    Old 01-14-2022, 02:34 PM   #4
    Steve135
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    Re: Capsules vs. Tablets ?

    I had a visit with URO today and asked him he told me they only came in Capsules, he looked it up and no Tablets. LOL! If I were able to post a picture I can clearly show you the Capsules I have taken for 2 1/2 years and the Tablets I just received. They are both Pfizer both a 40mg enzalutamide. He said the only reason to give Tablets vs. Capsules is smaller to take and able to cut it, if required. That was for any med. in general.
    steve

     
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    Old 01-14-2022, 07:01 PM   #5
    DjinTonic
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    Re: Capsules vs. Tablets ?

    This webpage:

    https://xtandi.com/how-to-take

    says "Swallow XTANDI capsules or tablets whole. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets."

    I have no personal knowledge other than what I'm seeing online--perhaps they are phasing the capsules out (?)

    Djin
    __________________
    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3-
    7-05-13 TURP for BPH (90→30 g) path neg. for PCa, then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Nodule negative for PCa. Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
    SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
    pT2c pN0 pMX, G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    Dry; ED OK with sildenafil
    Decipher 0.37 (Low Risk), uPSA: 0.010 (3 mo.)...0.020 (3 yr. 7 mo.)

     
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