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PSA is 45

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Old 10-08-2011, 06:10 PM   #1
Join Date: Oct 2011
Location: Savanna, Illinois USA
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Pennybug HB User
Question PSA is 45

My psa is 45 and out of 12 cores taken all were 80 to 100 percent cancerous and am told there is an 80 percent chance that cancer is already outside prostate. Had bone scan today so don't know the results yet.. Waiting is hard, Gleason is 4+ 3 =7 whatever that means. Has anyone here had a PSA of 45? What does it mean?

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Old 10-10-2011, 11:06 PM   #2
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Re: PSA is 45


A PSA at 45 is considered high (normal is up to 4). Your Gleason score of 4+3=7 is for an intermediate risk but the grade of 4 is for an aggressive type of cancer. These data with 12 cores (biopsy) positive and voluminous involvement is indicative that you got an advanced case of prostate cancer. Nevertheless, you are not alone. There are many guys in similar situation and even with must higher PSA levels, but have done well with treatments.

Other elements are important to understand better your status. The clinical stage would inform about the advancement (contained, localized, metastasized, etc.). Any symptom that made you to check for cancer or DRE are also elements that you will need to make a decision on a treatment. Your age and any other illness will weigh in your case too.
The bone scan will give you more details on the advancement of your case. An endorectal MRI would be helpful to give you an anatomical image of the areas around the prostate and check for localized metastases.

I recommend you to read books on prostate cancer and research in the net typing this sentence; “treatments for prostate cancer”. You should also be aware of the risks and side effects related to each type of treatment.

Here is a good book that may help in preparing a list of questions to your next doctors visit and to understand some comments from your doctor;
"100 QUESTIONS & ANSWERS ABOUT PROSTATE CANCER"; by Alan J. Wein and Pamela Ellsworth.

Welcome to the board.


Last edited by Baptista; 10-10-2011 at 11:16 PM.

Old 10-11-2011, 07:44 PM   #3
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Re: PSA is 45

Hi Pennybug,

I have just been diagnosed myself with prostate cancer and have a similar situation as yours. PSA 65, Gleason 4+3=7 and 80 % involvement of cancer in my prostate. I am 50.

It looks likely that there is metastasis in my case at least into the seminal vesicle as was revealed via an MRI. Likely beyond as well. Cat scan was negative as was a Prostascint test.

Shocking stuff I know and extremely difficult to digest.

You read stuff in older books or older stuff on the internet and you can break down in tears with the idea you'll be dead in a few years.

I've chosen hormone therapy which I start Friday. I'll likely do IMRT in a couple months. The package is kind of spooky sounding.....but it is what it is.

Good luck!


Old 10-12-2011, 05:52 AM   #4
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Re: PSA is 45

Dear Penny bug.

What was missing in my last post was that 95% of folks with advanced disease are still around after 10 years and are usually pretty healthy at that. I learned that here and am incredibly grateful for that tidbit. After I read that it made me able to view the cancer as something more manageable than immediately fatal. Please be very careful what you read.

Hang in there,


Old 11-08-2011, 06:04 PM   #5
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Re: PSA is 45

Pennybug and yarbo3,
Check out Proton Therapy, Conformal Beam, IMRT, CyberKnife, and surgery. I went to Loma Linda for Protons with good results but whatever your choice make sure it is a leading prostate cancer clinic. I had a failed RP surgery before I sought salvage therapy and like most other things your first chance is your best chance for a cure.
Good luck guys,

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