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  • PSA suddenly went up

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    Old 11-08-2012, 05:34 PM   #1
    fromKansas's Avatar
    Join Date: Nov 2012
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    fromKansas HB User
    PSA suddenly went up

    Age 63. No known prostate cancer history in family.

    Had pelvic and urinary symptoms off and on for last 15 years. Frequent urination, incomplete voiding, mild pain pelvic area. Prostatodynia suspected. Anxious personality.

    PSA has been steadily going up:
    2000 = 1.0; 2002 = 1.2; 2003=1.60; 2006=1.93
    2007 = 3.6; 2009 = 3.7; 2010=3.36; 2012 (September)=6.44

    This last one is really scaring me - almost doubled in about 18 months.
    I also had slight worsening of my uriniary and pelvic symptioms since last
    4 to 5 months.

    Urologist says he found some slight enlargement of my prostate in line with my age and some mild inflammation - based on DRE. He wants me to go for biopsy quickly.

    Does a mild BPH or mild inflammation cause such a spike in PSA ? Does worsening of the urinary symptoms lead to such PSA. It was steady for almost 4 years in the
    3.xx level and then a big jump to 6.44. If it had been cancer, would the PSA have stayed steady for 4 full years prior to the big jump ?

    Appreciate any comments based on experience or knowledge.

    Last edited by fromKansas; 11-08-2012 at 05:36 PM.

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    Old 11-11-2012, 05:25 PM   #2
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    Billy6 HB User
    Re: PSA suddenly went up

    Sounds like you are taking good care of your health with frequent PSA checks. My older brother had a gradually rising PSA and he was diagnosed with cancer after a biopsy when his PSA was 4.25. My younger brother had a jump to 6+ like yours and he was diagnosed with cancer after a biopsy. Those happened 10 years ago and they are both doing well with zero PSA's today.

    My PSA went up gradually and I had a biopsy when PSA was 4.5. The biopsy showed no cancer but an area of abnormal cells ( a PIN, prostatic intra epithelial neoplasia).One year later, I had a urinary tract infection whne my blood sample was taken for a PSA reading. It came out at 112. A repeat 4 months later showed PSA of 11. It took 6 months or more to get back to normal when the PSA was now 6+. A biopsy at this time showed cancer in 2 of 12 samples with a Gleason score of 7. My prostate was removed 3 months ago and the pathology looked like my 2 brothers.

    You should reduce your anxiety . You have done everything right and you may have discovered a cancer early, one that is slow-growing, and one that can be removed before it gets more serious. Your biopsy will yield the result. They will take 12 samples and examine each under a microscope. You might have no cancer. You might have an area of abnormal cells like my PIN. Or there might be one or more cancer samples. For these, there will be a Gleason score that is the sum of 2 numbers. The first is the worst cell pattern in the sample and the second is the most common cell pattern. 10 is the highest value indicating an agressive cancer and 1 is very low. My older brother had an 8 and I had a 7 (4+3).

    Some people have high PSA readings and no cancer. A friend of mine has a PSA of 9 that has been constant for several years and his biopsies show no cancer. Another person has had 11 biopsies with PSA's of 11 and he does not have cancer.

    So the biopsy is the result you need to proceed with the diagnosis. But you need not worry. If there is no cancer, you are good to go. If there is, you have caught a slow-growing cancer early that you will recover from completely. Be confidant, the future is going to good for you no matter the result. Three weeks after my surgery, I was on vacation in New Hampshire and later walked for 7 hours in New York City.

    Good luck.

    Last edited by Billy6; 11-11-2012 at 05:28 PM.

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