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Atypical of Undetermined Significance

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Old 08-05-2011, 04:23 PM   #1
Join Date: Aug 2011
Location: Chicago, IL
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kbsaccaro HB User
Atypical of Undetermined Significance

I just received my results from my thyroid FNA today and the diagnostic category was "atypia of undetermined significance". The diagnosis was: rare atypical follicular cells. There were rare clusters of follicular cells and enlarged and elongated nuclei with nuclear grooves, dense cytoplasm and rare calcifications. There were both follicular and Hurthle cells present.

It was recommended that I have a follow-up FNA biopsy in 3-6 months. From everything I've read/researched and have seen on this site and various threads, am I just prolonging the inevitable by holding off on a thyroidectomy?

I have requested a meeting with the surgeon who did my biopsy for a second opinion-it was my ENT who gave me the results today. Her advice was to wait and do the second biopsy in 3-6 months but she said she would also be comfortable recommending removal of the thyroid if that was the route I would be most comfortable with.

Totally confused at this point-the ambiguity seems to be common with FNA results of my kind as I've seen a lot of similar posts.

Thoughts, suggestions, feedback?

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Old 08-07-2011, 06:34 AM   #2
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Join Date: Jun 2006
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anxiousagain HB Useranxiousagain HB User
Re: Atypical of Undetermined Significance

From all the research I've done on my own nodule (my biopsy came back "suspicious for follicular neoplasm"), atypical of undetermined significance is a slightly better FNA result. The medical literature seems to suggest the chance of malignancy is 5-10%, about the same as it is for any nodule. That being said, now that you know it has abnormal cells in it, you have to make some choices. If it's not causing you any problems and is on the smaller side, I think your doctor's recommendation is very reasonable. It may not grow or it may. If it does then you would probably want to get it out. Because I'm in the same situation as you, I understand your anxiety. My chance of cancer is somewhat higher (20-30%) and my nodule is fairly sizable. I will therefore be having thyroid surgery tomorrow. Yes, the ambiguity frustratingly sucks! )

Old 08-08-2011, 06:38 AM   #3
Join Date: Aug 2011
Location: Chicago, IL
Posts: 2
kbsaccaro HB User
Re: Atypical of Undetermined Significance

Thank you for your response, anxiousagain. I hope your surgery goes well-sending good vibes your way!

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