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  • Can Wellbutrin lead to depression?

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    Old 03-14-2007, 11:49 AM   #1
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    Can Wellbutrin lead to depression?

    I was on zoloft (for panic) for 2 years (50-100mg) prescribed by my internist. Beginning of January, I found a psychiatrist and told him that I wanted to get off of Zoloft because it was causing me sever night sweats, too vivid dreams and affecting my orgasms. He suggested to try Wellbutrin, but since it isn’t known for helping anxiety – he suggested taking clonazepam too (.25 mg morning and night).

    I tapered off of the Zoloft for a few weeks (or was it one week)…stopping at 25 mg once per day, overlapping that week with150mg of Wellbutrin XL. About 4 weeks later, I became an emotional wreck. No depression until 4 weeks – which was really weird. Then all of the sudden – wamm – crying and an emotional weepy mess (not like me at all). This lasted for 3 week (until I could see my psyc again). After a lot of discussion he thinks I am ADD (which makes total sense) and put me on Adderall. Still taking the Wellbutrin (150) and only taking 0.25 clonazepam at night (which I don’t think I need anymore).

    My question is – could the wellbutrin be causing depression and now it is masked by the adderall? I want to stop taking the wellbutrin, but how do I tapper off when my pills are tiny 150mg roundish spherical-ish tabs?

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    Old 03-14-2007, 03:54 PM   #2
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    Re: Can Wellbutrin lead to depression?

    I took Wellbutrin to help stop smoking and I think it caused me anxiety (or panic) which caused me to have depression. Just a guess on my part.

    Old 03-15-2007, 12:24 AM   #3
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    Re: Can Wellbutrin lead to depression?

    Thanks Traveller. Anyone else have a reaction to Wellbutrin? Or, has anyone gone off of Wellbutrin and stop taking AD's? What were you side-effects?

    Old 03-15-2007, 04:53 AM   #4
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    Re: Can Wellbutrin lead to depression?

    Hi Skye,
    I went off Wellbutrin last week. I have major anxiety issues, (going through divorce, special needs daughter, looking for new job)...Anyway--I started having weeping/rage spells with high blood pressure, racing heart, palpitations and tremors. My doctor did a lot of blood tests, and EKG. All were normal. I was so scared and depressed and then I decided to look into the Wellbutrin. Ah, ha....It is a stimuant used for individuals to stop smoking. Basically, it put me on a constant adrenaline high--but in a bad way. I am back to feeling much better. I am taking zoloft. This works for me but not everyone. I did not lose any weight on Wellbutrin--in fact--I gained a lot. Weird. I have never had a weight issue and do now. For others it is a great medication, just not for me. I still have slight tremors from taking it. I was only on it 4 months. My symptoms started 6 weeks into taking it.

    Just goes to show you how different meds affect each of us.


    Old 03-15-2007, 07:24 PM   #5
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    Re: Can Wellbutrin lead to depression?

    I have struggled on and off for years trying to find a med that wil work for me. All the SSRI's tear my stomach up and I still don't have an answer. As for the Wellbutrin, it gave me such terrible anxiety and confusion taht I did not know what was wrong with me. I made a decision one day to leave the house and have a pastor sit with me for several hours, because I knew if I stayed home another minute I was going to shoot myself in the head. No joke. Turned out to be the drug. It wan't until later that I figured it out. Made me so paranoid that I was sitting in the parking lot of a department store unwilling to go in because there were people in there wanting to kill me. That is when I figured out it was a drug reaction. I started laughing at myself, enjoyed the rest of the day, and threw the Wellbutrin down the toilet where it belongs.

    Old 03-15-2007, 10:35 PM   #6
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    Re: Can Wellbutrin lead to depression?

    hi skye,

    the only thing wellbutrin did for me (beside increase my libido a bit--the reason for my taking it in the first place) was to give me this horrendous, extreme rage, constant irrtability, anger, agitation, and utter frustration. although i'm a relatively calm person, while on wellbutrin, i found myself so irritated--even by inanimate objects. it was a pretty terrible experience overall. no wonder it is usually given in addition to some kind of sedative (i.e., klonopin, xanax, ativan)!!!.

    it was not at all what i was looking for !!
    Be kinder than necessary,
    Because everyone you meet is fighting some kind of battle...

    Old 03-15-2007, 11:06 PM   #7
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    Re: Can Wellbutrin lead to depression?

    I just started taking it for ADHD and fatigue. I do feel a little jittery, but I'm only on 75mg once a day and on Monday I'll go to 150mg. I will keep checking back here for more responses. I'd be curious to hear of some positive feedback as well as negative thoughts on it.

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