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rydal 04-02-2010 09:13 PM

Changing from SSRIs to MAOIs
I have had depression for the last 20 years much of it severe. I have not been able to work for the last 15 years. Over the years I have been on a lot of different antidepressants, with varying success.

Most recently i had escitalopram and reboxetine which stopped working last christmas and I became suicidal. I had to go in to hospital for six weeks and they gradually boughts me off both SSRIs, not a good experience, I had physical withdrawal effects and very bad rebound anxiety. To counteract this I was put on propranolol and abilify and clonazepam and diazepam. According to my psychiatrist I have had to have six weeks with no ADs before I can safely start an MAOI (Nardil).

This has been six weeks of hell, due to finish Wednesday. I am surprised I have survived. The propranolol has now had to be stopped and my heart is racing again.

Has any one got experience of making such a change. And is an MAOI worth a try if all else has failed.

I sleep only about 2-3 hours in 24 and have all classic depression symptoms that are completely ruining my life and relationships. I do my best to implement self help strategies and try to keep busy. I am on a waiting list for extensive psychotherapy but the wait here in the UK is about one year.

greg1x 04-03-2010 04:41 PM

Re: Changing from SSRIs to MAOIs
I was on Nardil about 30 years ago. As long as you are aware of the drug, and food , interactions you should be fine. I do not remember near the adaptation period and side effects, with Nardil, as when I started Lexapro a couple of years ago. I stopped the Lexapro due to excessive weight gain, and have been on Wellbutrin, which has increased my anxiety considerably. Let us know how you do on Nardil.

NoPainToday 04-04-2010 08:15 AM

Re: Changing from SSRIs to MAOIs
I can identify with the above as I have been prescribed various antidepressants. Over time my doctor had me on Prozac, Lexapro, Cymbalta, and a variety of different prescription sleep- and anti-anxiety medications; mostly the so called z-drugs and benzodiazepines. Although some of them worked to suppress the side effects of the SSRI's, both the sleep and anxiety medications seemed to cause a rebound effect, and stopped working after few months when taken as directed and increasing the amount caused drowsiness and pretty much made me dysfunctional at work. Anyways, I got into a car crash about 3 years ago, which left me with broken ribs, legs, and spine issues that forced me to go through physiotherapy for about a year. This was also the first time that I had been prescribed narcotic pain medications for more than a day (due to a pulled wisdom teeth by my dentist) and I remember that although being in lots of pain daily, I did not take antidepressants nor anxiety or sleeping medications at that time, and for some reason I still managed to go through it pretty well emotionally. I am new here and don't know if I can make a reference to an article so I hope I don't violate any board rules but when I read the paragraph about 'Depression and Hydrocodone' at * I couldn't help but thinking that this may actually be the reason that I went through the whole experience the way I did. Knowing how i used to be, and how I am once again, I am seriously considering trying pain medications once again. After my accident I was prescribed Lortab for several months and this did indeed seem to control my depression very effectively while not having the side effects of the SSRI's although I am aware that addiction is obviously another factor that should be kept in mind. Since I still experience daily pain, and because I have a legit reason to justify future use of any Hydrocodone containing medications I could simply ask my physician who has prescribed them occasionally after the accident once the specialist stopped prescribing them. I do want to mention that I am not suicidal, and it is probably a bad idea to use any narcotic prescription drug if this was the case or if you have issues with addiction already, so I do not recommend it to anyone else, but on the other hand, many people especially elderly seem to use these drugs frequently, and I surprisingly discovered that few people I know confessed to using them mainly for mental relief! If anyone has personal experiences with the use of pain medications and its effect on depression I would greatly appreciate their feedback, or a private message if you prefer not make any such confessions on this forum. Thanks for listing and keep you head up!

trg247 04-04-2010 06:56 PM

Re: Changing from SSRIs to MAOIs
I have done it and spent six weeks in the hospital while it happened. MAOIs are known to help people that the newer drugs have been less than successful. I ended up stopping as there was blood pressure issues and I needed to go through dental surgery. On a positive note they did work for a while.

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