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Old 06-12-2012, 03:12 PM   #1
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Join Date: Nov 2010
Location: Oregon, USA
Posts: 24
adrienne4347 HB User

For me, Deplin is working wonders. Or more specifically, a balanced approach to the MTHFR genetic mutation that was sparked by a trial of Deplin is working wonders for my depression.

Due to a genetic mutation, ten percent of people have a severely reduced capacity to change the folic acid and B12 that is found in a lot of our food into the forms that they need to be in to be used by our bodies. A doctor figured out that I might be one of these people after hearing about my lifetime of treatment-resistant depression and my family history of early heart disease and blood clots and various mental illnesses. Turns out that this little genetic mutation can wreak all sorts of havoc on our brains and bodies because it causes nutritional deficiencies that hide from standard blood testing--if you get your B12 tested it will look high, because your body is unable to metabolize it.

Deplin is expensive but it's also a super-high-dose methylfolate that is overkill even for a lot of the people who have this problem. And I've found just as much or even more benefit from taking methyl B12 I got at the health food store for $10. I have read a few posts from people who took Deplin and maybe it helped but it was expensive and they quit taking it. Two things--it often won't work that well and may cause anxiety unless you are also getting methylated B12, aka methylcobalamin, and the dose is so high in those Deplin pills that I've been breaking them into fourths--so instead of $50 a month it's closer to $10.

Another thing is that a clean diet can really help. The fewer chemicals the better. One thing I didn't really understand until recently is that any chemicals you introduce into your body from your diet have to be processed by the same systems that produce your neurotransmitters and regulate your hormones--and can cause those things to get even more out of whack.

Just wanted to put this out there for folks because I feel SO MUCH BETTER and I know there are more people out there who would also feel better with some simple vitamins. A web search for MTHFR will bring up lots of info. It's complicated but worth reading about.

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TinoRock (06-26-2012)
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Old 06-21-2012, 10:21 AM   #2
Join Date: Jun 2012
Location: New Orleans, LA
Posts: 1
HollyRae HB User
Re: MTHFR/Deplin

I love the way you phrased that: "a balanced approach to the MTHFR genetic mutation". ?A lot of people who suffer with depression do not realize that they have this mutation. Deplin is basically just giving you something you are missing. I am so glad to hear it is making a difference for you.

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