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Perfumed Fan 10-03-2012 09:38 PM

Are there people whose bodies just won't adapt to metformin?
My doctor is trying to get me off insulin and added metformin two months ago. He started me with 1,000 mg a day and after a month raised it to 2,000 mg a day. I have had massive, explosive diarrhea every single day. I keep reading the diarrhea lasts only two weeks but mine does not get better, not even decreasing the dosage(I'm now down to 500 mg a day). Are there people who just can't take the stuff? The met really stabilized my glucose but I would rather stay on the syringe than live like this. :nono:

I am type 2, take 18 units Humulin 70/30 twice a day.

Cora1003 10-04-2012 06:30 AM

Re: Are there people whose bodies just won't adapt to metformin?
My husband at first wasn't event able to take a 500mg tablet without problems. He started at half a tab and worked his way up, very slowly. If you want to try the met, I would cut down even more, and then try to build up. But yes, some folks just can't take it.

SamQKitty 10-04-2012 01:43 PM

Re: Are there people whose bodies just won't adapt to metformin?
I agree with may have to cut back even more. In fact, you may want to stop the metformin until your digestive tract gets back to normal and then start the metformin at just 250 mg/day for a while, then very gradually work up to the corrective dose. Perhaps a week or two at 250 once a day, then a week or two at 250 twice a day, then a week or two of 500/250...etc. Although I've never taken metformin myself, I've seen other people say that by doing that very gradual introduction they were able to tolerate it and eventually get up to a therapeutic dose.

But, in the final analysis, if you absolutely can't tolerate the metformin, then insulin is a good way to go. However, I wouldn't recommend the 70/30 really does not do a good job of controlling blood sugars. The best way to go with insulin is to learn how to count carbs, and then take a long-acting insulin for basal needs (like Levemir or Lantus) and a rapid-acting insulin before each meal (like humalog or novolog.) When you count carbs, you and your doctor figure out what your insulin-to-carb ratio should be and then at each meal you figure out how many carbs you'll be eating, and bolus the rapid-acting insulin accordingly. There definitely is a learning curve (one to two months), but after a while you get pretty darned good at estimating carbs and then you're matching your insulin to your carbs. This gives the best control possible on insulin.


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