It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Drug Interactions / Side Effects Message Board


Post New Thread   Closed Thread
LinkBack Thread Tools Search this Thread
Old 03-19-2001, 01:45 AM   #1
Junior Member
Join Date: Mar 2001
Location: Florida
Posts: 28
Borgieskid HB User
Question Lasix-glucophage-coreg

Trying to find the drug interactions with glucophage, coreg and lasix. Dad had some symptoms of lactic acidosis... glucophage web site states "some" drugs may interact,but not very specific... any info appreciated.

Sponsors Lightbulb
Old 03-27-2001, 04:04 AM   #2
Junior Member
Join Date: Mar 2001
Location: Australia
Posts: 14
axe HB User

Frusemide (lasix), carvedilol (coreg), metformin (glucophage), are commonly all used in cardiac patients with diabetes. Rarely there are any problems unless the patient has underlying renal or hepatic impairment which alters the drug metabolism. The most serious as you stated is lactic acidosis. This is at most risk of occuring when the patient has renal impairment with a raise in the creatinine >150mmol/L The only interaction between these 3 medications you have listed is between frusemide and metformin as stated below:

Frusemide >< Metformin hydrochloride - 1 Interaction

The generic Frusemide increases toxicity of Metformin hydrochloride

Actions to be taken:
1. avoid combination
2. reduce the dosage of metformin

Drug Interaction Details:
High dose diuretic therapy can cause accumulation of biguanides, thus there is risk of an increase in toxicity. In addition, diuretics may have some hyperglycaemic properties.

Description of classes:
Frusemide belongs to the frusemide and related products class. Sulfonamide derived diuretic acting on the distal loop of Henle, with hypokalaemic effects.
Metformin hydrochloride belongs to the biguanides class. Antidiabetic drugs which increase uptake and utilisation of glucose at the cellular level. These agents do not induce insulin secretion.

Kind Regards

Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
Honest opinions /experiences with Lasix, considering this cvoor Lasik Eye Surgery 5 07-19-2008 07:18 AM
Lasix and Monopril Looly High & Low Blood Pressure 4 04-14-2007 08:04 PM
Lasix & Klor-Con question Sonia567 High & Low Blood Pressure 4 03-09-2007 08:44 AM
Lenin please compare Lasix to HCT cartner High & Low Blood Pressure 5 07-17-2006 06:32 AM
Aldactone vs. Lasix cartner High & Low Blood Pressure 8 03-12-2006 04:06 AM
Lasix and Potassium cartner High & Low Blood Pressure 6 03-08-2006 03:41 PM
What do you think of LASIX? Lenin High & Low Blood Pressure 33 02-26-2006 07:31 PM
Can lasix diuretic cause cholesterol to rise? jtu91952 High Cholesterol 3 12-23-2004 07:17 PM
Can lasix diuretic cause glucose or cholesterol increases? jtu91952 High Cholesterol 14 11-29-2004 07:22 AM
Heart Failure dianne12315 Heart Disorders 21 11-09-2004 01:38 PM

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 12:36 AM.

Site owned and operated by HealthBoards.comô
© 1998-2018 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!