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Bjork 03-27-2005 01:53 AM

Please Please Please Let Me Eat Grapefruit!!! :)
Hiya all,

I think that I may have posted here once, but I don't remember. It's been a long time. Anyway, here's my situation: I take a lot of medications. Eleven to be exact. I can't even remember them all at any given time because there are so many. They are basically for depression, anxiety, OCD, my Anorexia, and so forth. Along the line somewhere, in some treatment center, a long time ago, they told me that it was not advisable to eat Grapefruit or drink Grapefruit juice because it interferes with one or more of my medications, intensifying their effects (I believe?)

I had a thought recently though. I take the bulk of my meds immediately when I wake up, and then take the few remaining ones just before I go to bed at night. Can I have Grapefruit *in the middle of the day*? It would be several hours after I have taken my medications, and several hours before I have to take my nighttime ones. PLEASE Grapefruit seems to be the wonderfruit, I hear, and I have not had it in years! I so miss its taste! I'm also going to ask my pharmacist next time I see her. Thank you for all of your help!


zuzu8 03-27-2005 02:13 AM

Re: Please Please Please Let Me Eat Grapefruit!!! :)
It [I]would[/I] be a better idea to ask your pharmacist about each and every single medication. With some, or even [B]one[/B], grapefruit and/or grapefruit juice may be contraindicated [U]completely[/U]. In which case, even if it was okay to have grapfefruit with some of the others, you may have to steer clear altogether. Double check.

zuzu xx

bbalance 05-30-2005 03:46 AM

Re: Please Please Please Let Me Eat Grapefruit!!! :)
I have a script for Valium(diazapem) and the bottle specifically states not to eat grapefruit while on the med.

zeez 05-30-2005 05:59 AM

Re: Please Please Please Let Me Eat Grapefruit!!! :)
Hi Bjork,

That is so interesting that I had to look up some info on it. From what I've read, the reason not to have grapefruit is that there's an enzyme in it that increases the effect of certain medications. Here's a technical explanation, as I am not good at explaining things:

Grapefruit juice is a potent inhibitor of the intestinal cytochrome P-450 3A4 system (specifically: CYP3A4 - mediated drug metabolism) which is responsible for the first-pass metabolism of many medications. This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. In many cases, the increased serum drug levels can produce some readily observable symptoms. Here are a few examples of adverse effects that are possible when the following medications are taken concurrently with grapefruit. (1) Excessive sedation: benzodiazepines.
I left out the others since you are only concerned with Valium. Added with edit ---- oops, I thought you were concerned with Valium but that was bkfree. Chances are that the medication you were warned about falls into the category of benzowhatevers. You may want to take your meds to your pharmacist and ask.

Wow, I learned something new today. :)

If you love grapefruit so much, I would suggest talking to your doctor about an alternative drug, however, looking at the listing of drugs, I am not sure what would be a good substitute. I take Xanax-XR (extended release) once a day and there is no warning about grapefruit on it. I've also taken Klonopin in the past and it had no warning on it. I'm pretty sure those fall into the category of benzodiwhatevers.

Here's a listing of the drugs that grapefruit affects:

amiodarone astemizole alprazolam atorvastatin
benzodiazepines buspirone carbamazepine carvedilol
cerivastatin cilostazol clarithromycin Clomipramine
codeine cyclosporine dapsone dextromethorphan
diazepam diltiazem estrogens erythromycin
felodipine fentanyl finasteride haloperidol
indinavir lercanidipine lidocaine lovastatin
midazolam methadone nelfinavir nifedipine
nicardipine nimodipine nisoldipine nitrendipine
ondansetron paclitaxel progestins progesterone
quinidine ritonavir salmeterol saquinavir
simvastatin tacrolimus trazodone triazolam
vincristine zaleplon zolpidem

I wish you luck in finding a solution. I personally don't eat grapefruit - doesn't tork my turtle! Now I'd drink grapefruit juice if it had a little vodka in it.... ;)

Bell99 06-13-2005 09:10 AM

Re: Please Please Please Let Me Eat Grapefruit!!! :)
I take Buspar and it says don't eat or drink grapefruit juice too!
I don't like the Juice but sure miss the fruit for breakfast.

crushme 06-19-2005 08:30 PM

Re: Please Please Please Let Me Eat Grapefruit!!! :)
I would be interested to do a little mixing of grapefruit with xanax just to see what it actually did. Not a suggestion...but I might just try it sometime!

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