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  • Lipitor and Grapefruit

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    Old 11-10-2007, 06:20 PM   #1
    CtRich
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    Lipitor and Grapefruit

    I take 10 mg. of Lipitor in the evening. My choloesterol is 116.
    I've heard you should'nt mix Lipitor with any kind of grapefruit product, so I asked the pharmacist since I am on such a low dose if I could eat an
    occasional grapefruit. She said absolutely not.
    Ok, so then I asked my doctor and he said the pharmacist was exaggerating and to go ahead and eat a grapefruit, just not a bushel of them.
    So who is right?
    The pharmacist or the doctor?

     
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    Old 11-12-2007, 06:08 AM   #2
    KayakGuy
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    Re: Lipitor and Grapefruit

    When I was on Pravachol, Zocor, and Crestor, I asked the same question. My doctor said that since I took the statin at night and ate the 1/2 grapefruit in the morning it was not an issue. The statin would be out of the stomach by morning.

    Just be sure the Lipitor isn't lowering your testosterone levels.

     
    Old 04-22-2008, 09:23 PM   #3
    shadowrider84
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    Cool Re: Lipitor and Grapefruit

    Our local TV station had a story on it 3 years ago about a local guy who was on a cholesteral medication. He had drunk a 8 oz. glass of grapefruit juice and then went out to mow the lawn with a riding lawnmower. He passed out and his wife found him in the yard and the lawn mower was still running. The rescue squad couldn't save him and he was DOA on arrival at the hospital.

    I've not had any grapefruit in going on 5 years and I'm still kicking.

     
    Old 04-23-2008, 08:58 AM   #4
    maverick22222
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    Re: Lipitor and Grapefruit

    Quote:
    Originally Posted by CtRich View Post
    I take 10 mg. of Lipitor in the evening. My choloesterol is 116.
    I've heard you should'nt mix Lipitor with any kind of grapefruit product, so I asked the pharmacist since I am on such a low dose if I could eat an
    occasional grapefruit. She said absolutely not.
    Ok, so then I asked my doctor and he said the pharmacist was exaggerating and to go ahead and eat a grapefruit, just not a bushel of them.
    So who is right?
    The pharmacist or the doctor?
    The Pharmacist is right.

    An unusual discovery in 1989 found that grapefruit juice has the potential to interact with an important biologic pathway, known as cytochrome P450, that is involved in the metabolism of many commonly used drugs. A specific form of this pathway, known as CYP3A4, is present in the liver and the intestines. Grapefruit juice appears to bind to this pathway in the intestine, preventing the drugs from being absorbed through the intestine and elevating the circulating level of the drug in the body.

    As little as 250 ml of grapefruit juice can affect metabolism of some drugs, lasting for up to 24 hours. Hope this helps!

    Last edited by maverick22222; 04-23-2008 at 08:59 AM.

     
    Old 05-01-2008, 03:20 PM   #5
    Chas19
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    Re: Lipitor and Grapefruit

    Your MD. THe grapefruit reaction is real, but it applies to much larger quantities as found in the juice as distinguished from just the fruit itself. I am Lipitor, eat a half grapfruit from time to time. What a loss. Right, not a "carload," but you get the point.

     
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