It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Genetic Disorders Message Board

  • Hereditary Clotting Disorders

  • Post New Thread   Reply Reply
    Thread Tools Search this Thread
    Old 11-13-2012, 11:37 PM   #1
    Junior Member
    Join Date: Nov 2012
    Posts: 28
    DaveO48 HB UserDaveO48 HB User
    Hereditary Clotting Disorders

    In 2006 I had a total right knee replacement. I also developed a blood clot in the Popliteal vein. I was put on Warfarin (Coumadin) for 6 months. The clot cleared up. I was taken off warfarin, the next year I developed a clot in the same vein but left leg. No surgery before the clot happened. Back on warfarin INR 2.5. Next, while on warfarin INR 2.5, I developed PE's in both lungs. ICU for 10 days heparin shots and after release was sent to hematologist. He ran a lot of tests with the finding of compound heterozygous MTHFR C677T and A1298C, Factor V Leiden homozygous R506Q, and Prothrombin/Factor II Mutation heterozygous G20210A.
    That's a mouthful but, suffice to say, I will be on warfarin as long as I live.
    I have my INR checked every 2 weeks with a goal to maintain my INR between 3.5 and 4. As I am extremely sensitive to warfarin I take 2MG each day except on Sunday and Thursday when I take 3 MG. My INR has fluctuated quite a bit from as low as 2.1 when something I ate interfered to 5.9 when I had to take a sequence of antibiotics.
    The pulmonary embolisms left me with chronic bronchitis and aversion to cold weather.
    An unexpected change since my INR has been raised is the edema in both of my legs below the knees has subsided more so in my left leg that still shows a clotted vein 23mm in length. I was told that my body had developed an alternative return route bypassing the clogged vein.
    I have a brother and a sister that have similar genetic problems. I also have a sister that has Marfans Syndrome but not the clotting problems we have.
    I have lived thru 5 ER visits from this and still do not know all of the ramifications for this genetic disorder, a work in progress.
    Other problems include: Tinnitis, osteoarthritis, spinal stenosis, renal cysts, non alcoholic steatohepatitis, knee replacement, 3 rotatorcuff surgeries, 2 angioplasties, one heart attack, high arches and hammertoes, burst fracture of L1,and maxillary sinus fractures.
    I take an extensive list of medications but now have "normal" blood chemistry. Because of the many medications I take I find my INR makes frequent excursions out of therapeutic range.

    Reply With Quote
    Sponsors Lightbulb
    Old 07-17-2017, 03:29 PM   #2
    rosier's Avatar
    Join Date: Sep 2011
    Location: kansas city missouri usa
    Posts: 307
    rosier HB Userrosier HB Userrosier HB Userrosier HB Userrosier HB Userrosier HB User
    Re: Hereditary Clotting Disorders

    It is quite common to have blood clots. You should be asking your doctors' about if it is genetic or not. It never hurts to ask the doctors' questions, for they are trained to be the medical experts. You can do this, ask questions because education about health issues are key to your overall health approach. Good luck and ask questions. Hugs for today.

    Never give up.

    Last edited by rosier; 07-17-2017 at 03:30 PM. Reason: spelling

    Reply With Quote
    Reply Reply

    Related Topics
    Thread Thread Starter Board Replies Last Post
    Hereditary disorders with heavy metals i555007 Genetic Disorders 2 10-12-2012 11:20 AM

    Thread Tools Search this Thread
    Search this Thread:

    Advanced Search

    Posting Rules
    You may not post new threads
    You may not post replies
    You may not post attachments
    You may not edit your posts

    BB code is On
    Smilies are On
    [IMG] code is Off
    HTML code is Off
    Trackbacks are Off
    Pingbacks are Off
    Refbacks are Off

    Sign Up Today!

    Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

    I want my free account

    All times are GMT -7. The time now is 06:10 PM.

    2019 MH Sub I, LLC dba Internet Brands. All rights reserved.
    Do not copy or redistribute in any form!