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ARIZONA73 11-15-2004 08:16 PM

Re: Ed With Zocor
 
Well alright. You just point me to a study which proves beyond any reasonable doubt that significant cholesterol reduction cannot possibly result in lower levels of sex hormones.

rahod 11-15-2004 10:04 PM

Re: Ed With Zocor
 
[QUOTE=ARIZONA73]Well alright. You just point me to a study which proves beyond any reasonable doubt that significant cholesterol reduction cannot possibly result in lower levels of sex hormones.[/QUOTE]

No dice :) ..You made the claim ..now prove it.

heart44 11-15-2004 10:45 PM

Re: Ed With Zocor
 
[QUOTE=rahod]Show me one study that links low cholesterol that a statin would give (total 140 on the lower end) to hormone deficiency. Secondly, LOW hormone level alone does not cause ED..it effects LIBIDO.[/QUOTE]
STUDY: E Bruckert et al. Men treated with hyoplipidaemic drugs complain more frequently of erectile dysfunction.
J Clin Pharm Ther 1996 21: 89-94.

RESULTS:
* Case reports linked both fibrates and statins with erectile dysfunction in a small number of men.
* Data from randomised clinical trials showed no difference between simvastatin and placebo in the 4S study (37/1814 on simvastatin, 28 of 1803 on placebo), but erectile dysfunction was not reported in other randomised trials.
* One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic with matched controls. Both fibrates and statins were independent predictors of erectile dysfunction with odds ratios of about 1.5.
* Regulatory agencies in Australia and the UK had yellow card reports of erectile dysfunction in men on lipid lowering drugs, both fibrates and statins. * In a small number of men, withdrawal of the lipid-lowering drug and rechallenge resulted in recurrent symptoms, though usually not a blind rechallenge.
* One useful observation was that drug switching resolved the problem in a number of cases.


[list][/list]

rahod 11-15-2004 11:23 PM

Re: Ed With Zocor
 
[QUOTE=heart44]STUDY: E Bruckert et al. Men treated with hyoplipidaemic drugs complain more frequently of erectile dysfunction.
J Clin Pharm Ther 1996 21: 89-94.

RESULTS:
* Case reports linked both fibrates and statins with erectile dysfunction in a [B]small number [/B] of men.
* [B]Data from randomised clinical trials showed no difference between simvastatin and placebo [/B] in the 4S study (37/1814 on simvastatin, 28 of 1803 on placebo), but erectile dysfunction was not reported in other randomised trials.
* One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic with matched controls. Both fibrates and statins were independent predictors of erectile dysfunction with odds ratios of about 1.5.
* Regulatory agencies in Australia and the UK had yellow card reports of erectile dysfunction in men on lipid lowering drugs, both fibrates and statins. * In a small number of men, withdrawal of the lipid-lowering drug and rechallenge resulted in recurrent symptoms, [B]though usually not a blind rechallenge.[/B]* One useful observation was that [B]drug switching resolved the problem in a number of cases. [/B]

[list][/list][/QUOTE]

Doesn't look like much to me...READ THE [B]BOLD [/B] PRINT

ARIZONA73 11-16-2004 10:50 AM

Re: Ed With Zocor
 
Many people are under the illusion that LDL is merely just some wicked, evil substance which should be attacked with a vengeance by any means possible, with total disregard to the essential functions that it performs inside our bodies.

In his book "Controlling Cholesterol", doctor Kenneth H. Cooper stated the following in his discussion about LDL:

"LDLs are very rich in cholesterol. Much of the cholesterol in the bloodstream resides in these LDLs, and this cholesterol can be used in essential ways by various body tissues. For example, some of the LDLs are pulled out of the blood by receptors on the body's cells. The cholesterol in these LDLs then proceeds to play a vital role in the cell's membranes. In addition, LDL cholesterol is used in the production of steroid hormones in the adrenal glands and the sex organs, and it participates in the formation of bile acids in the liver."

So, is it possible for LDL to be lowered too much, to the extent that hormone levels can be adversely impacted? I would tend to think so. Lower isn't always necessarily better. Once you go beyond a certain point, there are bound to be consequences, especially when you are dealing with a substance which performs many essential bodily functions.

heart44 11-16-2004 11:29 PM

Re: Ed With Zocor
 
Case reports
Cases of ED were first reported after clofibrate. Those described by Schneider showed recovery after drug withdrawal and recurrence on rechallenge. Five reports identified seven cases of ED following gemfibrozil. Rechallenge confirmed the effect in two. Therapy with bezafibrate was without adverse effect in three of these patients, but clofibrate had a similar effect in one.

ED in association with statins was first reported by Halkin et al. where both lovastatin and pravastatin separately caused ED in a 57-year-old man. Jackson reported five cases of ED with simvastatin at doses of 10 and 20 mg. Sexual function was restored within 1 week of stopping the drug. Two patients were rechallenged and impotence recurred. Alternative lipid-lowering therapies (fluvastatin or fenofibrate) did not cause this effect in these patients.

Information from regulatory agencies
The Australian Adverse Drug Reaction Advisory Committee (ADRAC) reports 11 cases of ED due to clofibrate, six due to gemfibrozil and 42 cases of ED in association with simvastatin. The men affected by simvastatin ranged in age from 43 to 72 years (median 57) and the onset occurred from 48 hours to 27 months (median 6 weeks) after the drug was started. Simvastatin was the only drug implicated in 35 of the reports and, in four rechallenged, the symptom recurred. Of the 29 reports in which recovery was mentioned, 14 had recovered after discontinuing the drug whereas in the other 15 there had been no recovery at the time the report was submitted. ADRAC also lists 11 reports of gynaecomastia in association with simvastatin.

Statins inhibit the rate-limiting step of cholesterol synthesis (HMG-CoA reductase) and hence potentially may inhibit the synthesis of steroid hormones derived from cholesterol, including tetosterone. There is evidence that simvastatin causes minor changes in circulating androgen concentrations in asymptomatic men.

jeankb 11-17-2004 03:59 AM

Re: Ed With Zocor
 
thank you all for your replys - husband has been taking half a pill of zocor daily (instead of 40 mg he is taking 20 mg) his cholesterol was 136 after taking 40mg for 6 weeks -it will be interesting to see next blood test - but the ED is not as much a problem now and his state of mind is much improved because of it - meanwhile he has been exercising and losing weight also. He has been thru many test to see if he had any nerve or blood vessel damage and test were negative so I believe it was the zocor unless there is some recovery time after going from a very high TC and high trigs to normal levels - any thoughts on that---


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